Gata4 - GATA binding protein 4 Gene

Also Known as Gata-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14463

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including heart development; negative regulation of cell death; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of gene expression. Located in chromatin and nucleus. Is expressed in several structures, including early conceptus; embryo mesenchyme; gut; heart; and reproductive system. Used to study atrial heart septal defect 2 and congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Gata4 Products (4)

mRNA Protein Name
NM_001310610.1 NP_001297539.1 transcription factor GATA-4 isoform 1
NM_008092.4 NP_032118.2 transcription factor GATA-4 isoform 2
NM_001310610.1 NP_001297539.1 transcription factor GATA-4 isoform 1
NM_008092.4 NP_032118.2 transcription factor GATA-4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
8007990 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
9738004 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12845333 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15539431 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16603706 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
21379568 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9584153 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8455608 MGI
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
11724781 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Sertoli cell differentiation IMP
IMP: Inferred from mutant phenotype
21172404 MGI
involved in atrial septum primum morphogenesis IMP
IMP: Inferred from mutant phenotype
17643447 MGI
involved in atrioventricular canal development IGI
IGI: Inferred from genetic interaction
21330551 MGI
involved in atrioventricular valve formation IGI
IGI: Inferred from genetic interaction
21330551 MGI
acts upstream of or within atrioventricular valve morphogenesis IGI
IGI: Inferred from genetic interaction
19084512 MGI
acts upstream of or within cardiac muscle cell differentiation IGI
IGI: Inferred from genetic interaction
18400219 MGI
acts upstream of or within cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
18400219 MGI
acts upstream of cardiac muscle cell proliferation IGI
IGI: Inferred from genetic interaction
19084512 MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress IMP
IMP: Inferred from mutant phenotype
20705924 MGI
acts upstream of or within cardiac muscle tissue development IGI
IGI: Inferred from genetic interaction
20705924 MGI
involved in cardiac muscle tissue regeneration IDA
IDA: Inferred from direct assay
25590961 MGI
involved in cardiac right ventricle morphogenesis IMP
IMP: Inferred from mutant phenotype
17643447 MGI
involved in cardiac septum development IGI
IGI: Inferred from genetic interaction
21330551 MGI
acts upstream of or within cell-cell signaling IMP
IMP: Inferred from mutant phenotype
16127717 MGI
acts upstream of or within cellular response to follicle-stimulating hormone stimulus IDA
IDA: Inferred from direct assay
9231805 MGI
acts upstream of or within cellular response to gonadotropin stimulus IDA
IDA: Inferred from direct assay
9231805 MGI
acts upstream of or within embryonic digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
16127717 MGI
acts upstream of or within embryonic foregut morphogenesis IMP
IMP: Inferred from mutant phenotype
9136932 MGI
acts upstream of or within embryonic heart tube anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
9136932 MGI
acts upstream of or within embryonic heart tube development IMP
IMP: Inferred from mutant phenotype
9136932 MGI
acts upstream of or within embryonic morphogenesis IMP
IMP: Inferred from mutant phenotype
9136932 MGI
acts upstream of or within endocardial cushion development IGI
IGI: Inferred from genetic interaction
19084512 MGI
involved in endocardial cushion development IMP
IMP: Inferred from mutant phenotype
17643447 MGI
acts upstream of or within endoderm formation IMP
IMP: Inferred from mutant phenotype
8582296 MGI
acts upstream of or within epithelial cell fate commitment IMP
IMP: Inferred from mutant phenotype
16940177 MGI
acts upstream of or within gastrulation with mouth forming second IMP
IMP: Inferred from mutant phenotype
9136933 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
11297508 MGI
involved in heart looping IMP
IMP: Inferred from mutant phenotype
15310850 MGI
involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
17975667 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
9136932 MGI
acts upstream of or within lung lobe formation IMP
IMP: Inferred from mutant phenotype
17142311 MGI
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
23558708 MGI
involved in negative regulation of apoptotic signaling pathway IDA
IDA: Inferred from direct assay
25590961 MGI
involved in negative regulation of cardiac muscle cell apoptotic process IGI
IGI: Inferred from genetic interaction
25590961 MGI
involved in negative regulation of connective tissue replacement IDA
IDA: Inferred from direct assay
25590961 MGI
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
25590961 MGI
acts upstream of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
25590961 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14978031 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12845333 MGI
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
17975667 MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation IGI
IGI: Inferred from genetic interaction
19084512 MGI
involved in positive regulation of cell cycle IDA
IDA: Inferred from direct assay
23558708 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
23558708 MGI
involved in positive regulation of miRNA transcription IDA
IDA: Inferred from direct assay
25590961 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8007990 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12845333 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15539431 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17272516 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21220346 MGI
involved in positive regulation of vascular endothelial growth factor production IDA
IDA: Inferred from direct assay
17975667 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9738004 MGI
acts upstream of or within regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
15902305 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
20833366 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
18400219 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8007990 MGI
acts upstream of or within response to estrogen IDA
IDA: Inferred from direct assay
9231805 MGI
involved in response to retinoic acid IDA
IDA: Inferred from direct assay
18439490 MGI
acts upstream of or within seminiferous tubule development IMP
IMP: Inferred from mutant phenotype
21172404 MGI
acts upstream of or within signal transduction involved in regulation of gene expression IDA
IDA: Inferred from direct assay
18462699 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
21172404 MGI
acts upstream of or within tube morphogenesis IGI
IGI: Inferred from genetic interaction
18400219 MGI
acts upstream of or within ventricular cardiac muscle tissue development IGI
IGI: Inferred from genetic interaction
19084512 MGI
involved in ventricular septum development IMP
IMP: Inferred from mutant phenotype
17643447 MGI
involved in wound healing IDA
IDA: Inferred from direct assay
25590961 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
21029371 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12801993 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor GATA-4

  • GATA-binding factor 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-128326 ZAK-IN-1 Inhibitor 98.43% Unkown
HY-103484 GATA4-NKX2-5-IN-1 Inhibitor 99.24% Unkown
HY-RS05292 GATA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174481 Mouse Gata4 mRNA / Unkown
HY-174673 Human GATA4 mRNA / Unkown
HY-RS18176 Gata4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24650 Gata4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gata4 NCBI NCBI:2626