Gcg - glucagon Gene

Also Known as Glu; PPG; GLP-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14526

Summary

This gene encodes glucagon, a pancreatic hormone that counteracts the action of Insulin in the bloodstream. The encoded protein is processed to generate glucagon and two Other glucagon-like peptides, GLP1 and GLP2. Glucagon stimulates gluconeogenesis, glycogenolysis and lipolysis. GLP1 induces secretion of Insulin, suppresses glucagon secretion and inhibits feeding. GLP2 induces intestinal absorption of glucose by stimulating the growth of intestinal cells and preventing Apoptosis. [provided by RefSeq, Apr 2015]

Gcg Products (1)

mRNA Protein Name
NM_008100.4 NP_032126.1 pro-glucagon preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables receptor ligand activity IDA
IDA: Inferred from direct assay
30380405 MGI
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
19915011 MGI
involved in cellular response to glucagon stimulus IDA
IDA: Inferred from direct assay
30380405 MGI
acts upstream of gluconeogenesis IDA
IDA: Inferred from direct assay
24051374 MGI
involved in glucose homeostasis IDA
IDA: Inferred from direct assay
22037645 MGI
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
19915011 MGI
acts upstream of or within negative regulation of execution phase of apoptosis IDA
IDA: Inferred from direct assay
19915011 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
19915011 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
19915011 MGI
involved in positive regulation of calcium ion import IDA
IDA: Inferred from direct assay
19915011 MGI
acts upstream of or within positive regulation of gluconeogenesis IDA
IDA: Inferred from direct assay
24051374 MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
19915011 MGI
involved in positive regulation of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
19915011 MGI
involved in positive regulation of peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
19915011 MGI
involved in positive regulation of protein binding IDA
IDA: Inferred from direct assay
19915011 MGI
involved in positive regulation of protein kinase activity IDA
IDA: Inferred from direct assay
19915011 MGI
involved in protein kinase A signaling IMP
IMP: Inferred from mutant phenotype
19915011 MGI
acts upstream of or within regulation of insulin secretion IDA
IDA: Inferred from direct assay
14736883 MGI
involved in regulation of insulin secretion IDA
IDA: Inferred from direct assay
22037645 MGI
involved in response to activity IDA
IDA: Inferred from direct assay
22037645 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17928203 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
17693256 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
30380405 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pro-glucagon

  • glucagon-like peptide I

Orthologs Information

Species Symbol Source ID
Homo sapiens Gcg NCBI NCBI:2641