Gclc - glutamate-cysteine ligase, catalytic subunit Gene

Also Known as Glclc; GLCL-H; Ggcs-hs; D9Wsu168e

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14629

Summary

Enables glutamate-cysteine Ligase activity. Acts upstream of or within several processes, including glutathione biosynthetic process; negative regulation of apoptotic signaling pathway; and regulation of cellular protein metabolic process. Located in cytosol. Part of glutamate-cysteine Ligase complex. Is expressed in several structures, including alimentary system; central nervous system; integumental system; sensory organ; and urinary system. Used to study cataract. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine Ligase deficiency; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine Ligase catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Gclc Products (1)

mRNA	Protein	Name
NM_010295.2	NP_034425.1	glutamate--cysteine ligase catalytic subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glutamate-cysteine ligase activity	IDA IDA: Inferred from direct assay	10966520	MGI
enables glutamate-cysteine ligase activity	IMP IMP: Inferred from mutant phenotype	11118286	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12384496	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within L-ascorbic acid metabolic process	IMP IMP: Inferred from mutant phenotype	11118286	MGI
acts upstream of or within glutathione biosynthetic process	IDA IDA: Inferred from direct assay	16081425	MGI
acts upstream of or within glutathione biosynthetic process	IMP IMP: Inferred from mutant phenotype	10805773	MGI
acts upstream of or within glutathione metabolic process	IMP IMP: Inferred from mutant phenotype	11118286	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	15288121	MGI
acts upstream of or within negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	15288121	MGI
acts upstream of or within negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	17189825	MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	17189825	MGI
acts upstream of or within regulation of mitochondrial depolarization	IGI IGI: Inferred from genetic interaction	15288121	MGI
acts upstream of or within response to arsenic-containing substance	IMP IMP: Inferred from mutant phenotype	17189825	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	17189825	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	12384496	MGI
part of glutamate-cysteine ligase complex	IDA IDA: Inferred from direct assay	12384496	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
glutamate--cysteine ligase catalytic subunit	GCS heavy chain gamma GCS-HS gamma-ECS gamma-glutamylcysteine synthetase heavy subunit

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W015600	2-Acetamidophenol		99.73%	Unkown
HY-171705	KMS99220		99.48%	Unkown
HY-N1970	5,7-Dihydroxychromone		99.94%	Unkown
HY-147517	Keap1-Nrf2-IN-9	Inhibitor	98.52%	Unkown
HY-W015600S	2-Acetamidophenol-d3		99.48%	Unkown
HY-RS05333	GCLC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-184266	GCLCi0	Inducer	/	Unkown
HY-184267	GCLCi1		/	Unkown
HY-N17732	7-Hydroxy-5,3'4'-trimethoxyflavanone		/	Unkown
HY-N17855	Guavinoside B	Inhibitor	/	Unkown
HY-N1970R	5,7-Dihydroxychromone (Standard)		/	Unkown
HY-RS17688	Gclc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24150	Gclc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gclc	NCBI	NCBI:2729