S1pr2 - sphingosine-1-phosphate receptor 2 Gene

Also Known as Edg5; H218; LPb2; S1P2; Gpcr13; 1100001A16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14739

About S1pr2

Chromosome 9: 20,873,657-20,888,077 reverse strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 192 orthologues, 18 paralogues and is associated with 56 phenotypes. Broad expression in lung adult (RPKM 19.6), limb E14.5 (RPKM 17.) and 24 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity and signaling receptor binding activity. Involved in positive regulation of peptidyl-threonine phosphorylation and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within negative regulation of excitatory postsynaptic potential. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness 68 and non-Hodgkin lymphoma. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

S1pr2 Products (1)

mRNA Protein Name
NM_010333.4 NP_034463.2 sphingosine 1-phosphate receptor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24453941 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
11553273 MGI
acts upstream of or within negative regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
11553273 MGI
involved in positive regulation of peptidyl-threonine phosphorylation IMP
IMP: Inferred from mutant phenotype
23106337 MGI
involved in regulation of postsynapse assembly EXP
EXP: Inferred from Experiment
26748478 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
26748478 MGI
involved in sphingosine-1-phosphate receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23106337 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
26748478 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
26748478 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
35781853 MGI
is active in presynapse IEP
IEP: Inferred from expression pattern
35781853 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1pr2 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (34 - 298)

7tm_GPCRs

7tm_GPCRs: cd14964 (35 - 59)

7tm_GPCRs

7tm_GPCRs: cd14964 (68 - 89)

7tm_GPCRs

7tm_GPCRs: cd14964 (105 - 127)

7tm_GPCRs

7tm_GPCRs: cd14964 (149 - 165)

7tm_GPCRs

7tm_GPCRs: cd14964 (186 - 209)

7tm_GPCRs

7tm_GPCRs: cd14964 (231 - 253)

7tm_GPCRs

7tm_GPCRs: cd14964 (266 - 291)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 2

  • G-protein coupled receptor 13

  • S1P receptor 2

  • S1P receptor Edg-5

  • endothelial differentiation G-protein coupled receptor 5

  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 5

  • lysophospholipid receptor B2

  • sphingosine 1-phosphate receptor Edg-5

  • sphingosine-1-phosphate receptor S1P(2)

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12355 Siponimod Agonist 99.95% Yes
HY-12355A Siponimod hemifumarate Agonist 99.85% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-120409 AB1 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111253 CYM-5478 Agonist 99.90% Unkown
HY-139310 GLPG2938 Antagonist 99.94% Unkown
HY-176533 S1PR5-IN-1 Inhibitor 99.58% Unkown
HY-N1423B Glycocholic acid hydrate Activator 99.85% Unkown
HY-113934 L-threo Lysosphingomyelin (d18:1) Agonist 98.0% Unkown
HY-182618 XAX-162 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens S1pr2 NCBI NCBI:9294