Heph - hephaestin Gene

Also Known as Cpl; sla; mKIAA0698; C130006F04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15203

Summary

Predicted to enable copper ion binding activity; ferrous iron binding activity; and ferroxidase activity. Acts upstream of or within erythrocyte differentiation. Predicted to be located in basolateral plasma membrane and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Orthologous to human HEPH (hephaestin). [provided by Alliance of Genome Resources, Apr 2022]

Heph Products (4)

mRNA Protein Name
NM_001159627.1 NP_001153099.1 hephaestin isoform 1 precursor
NM_001159628.1 NP_001153100.1 hephaestin isoform 3 precursor
NM_010417.2 NP_034547.2 hephaestin isoform 1 precursor
NM_181273.4 NP_851790.1 hephaestin isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ferroxidase activity IDA
IDA: Inferred from direct assay
14751926 MGI
Biological Process GO Annotation Evidence References Source
involved in intestinal iron absorption IMP
IMP: Inferred from mutant phenotype
9988272 MGI
involved in multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
9988272 MGI
involved in positive regulation of iron export across plasma membrane IDA
IDA: Inferred from direct assay
30647129 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hephaestin

  • haphaestin

  • sex linked anemia

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06124 HEPH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18035 Heph Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24509 Heph Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Heph NCBI NCBI:9843