Hfe - homeostatic iron regulator Gene

Also Known as MR2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15216

Summary

Enables Transferrin Receptor binding activity. Involved in positive regulation of gene expression. Acts upstream of or within hormone biosynthetic process and multicellular organismal iron ion homeostasis. Part of HFE-transferrin receptor complex. Is expressed in brain; choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; and metencephalon part of 4th ventricle choroid plexus. Used to study hemochromatosis type 1. Human ortholog(s) of this gene implicated in several diseases, including acute porphyria (multiple); arthritis (multiple); bone marrow Cancer (multiple); hemochromatosis (multiple); and liver disease (multiple). Orthologous to human HFE (homeostatic iron regulator). [provided by Alliance of Genome Resources, Apr 2022]

Hfe Products (2)

mRNA Protein Name
NM_001347493.1 NP_001334422.1 hereditary hemochromatosis protein homolog isoform b precursor
NM_010424.5 NP_034554.2 hereditary hemochromatosis protein homolog isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables transferrin receptor binding IPI
IPI: Inferred from physical interaction
16893896 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within hormone biosynthetic process IMP
IMP: Inferred from mutant phenotype
15914561 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
10077651 MGI
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
24904118 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24904118 MGI
Cellular Component GO Annotation Evidence References Source
part of HFE-transferrin receptor complex IDA
IDA: Inferred from direct assay
16893896 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hereditary hemochromatosis protein homolog

  • hemochromatosis

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06149 HFE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18894 Hfe Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25385 Hfe Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992072 Anti-Human/Mouse CD95 Antibody (HFE7A) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hfe NCBI NCBI:3077