Hspa1b - heat shock protein 1B Gene

Also Known as Hsp70; hsp68; HSP70B1; Hsp70-1; Hsp70.1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15511

Summary

Enables protein folding chaperone. Involved in protein folding. Acts upstream of or within binding activity of sperm to zona pellucida; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; and response to heat. Located in cell body and mitochondrion. Part of zona pellucida receptor complex. Is expressed in early conceptus; embryo; and humerus. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; obesity; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract Infection. Orthologous to human HSPA1B (heat shock protein family A (HSP70) member 1B). [provided by Alliance of Genome Resources, Apr 2022]

Hspa1b Products (1)

mRNA Protein Name
NM_010478.2 NP_034608.2 heat shock 70 kDa protein 1B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11116152 MGI
enables protein folding chaperone IDA
IDA: Inferred from direct assay
27496612 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within binding of sperm to zona pellucida IDA
IDA: Inferred from direct assay
21880732 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
11879190 MGI
acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
11879190 MGI
involved in protein folding IDA
IDA: Inferred from direct assay
27496612 MGI
acts upstream of or within response to heat IDA
IDA: Inferred from direct assay
18755693 MGI
Cellular Component GO Annotation Evidence References Source
located in cell body IDA
IDA: Inferred from direct assay
21880732 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
9122205 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
17376863 MGI
part of zona pellucida receptor complex IDA
IDA: Inferred from direct assay
21880732 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heat shock 70 kDa protein 1B

  • 68 kDa heat shock protein

  • heat shock 70 kDa protein 1

  • heat shock 70kDa protein 1B

  • heat shock protein 70.1

  • heat shock protein, 70 kDa 1

Hspa1b Antibodies

Cat. No. Product Name Application Reactivity
HY-P80185 Hsp70 Antibody (YA359) WB, ICC/IF, IHC-P, FC Human, Mouse, Rat
HY-P80412 Hsp70 Antibody (YA728) WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P80712 Hsp70 1A Antibody (YA727) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P80713 Hsp70 1B Antibody (YA358) WB, IHC-P, IP Human, Mouse, Rat
HY-P80713A Hsp70 1B Antibody (YA358)(PBS only) WB, IHC-P, IP Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19261 Hspa1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06425 HSPA1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117252 HS-72 Inhibitor / Unkown
HY-RS25750 Hspa1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspa1b NCBI NCBI:3304