Ids - iduronate 2-sulfatase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15931

Summary

Enables sulfuric ester hydrolase activity. Predicted to be involved in glycosaminoglycan catabolic process. Located in lysosome. Is expressed in nervous system and neural retina. Used to study mucopolysaccharidosis II. Human ortholog(s) of this gene implicated in mucopolysaccharidosis II. Orthologous to human IDS (iduronate 2-sulfatase). [provided by Alliance of Genome Resources, Apr 2022]

Ids Products (12)

mRNA Protein Name
NM_001401926.1 NP_001388855.1 iduronate 2-sulfatase isoform 2 precursor
NM_001401927.1 NP_001388856.1 iduronate 2-sulfatase isoform 2 precursor
NM_001401929.1 NP_001388858.1 iduronate 2-sulfatase isoform 3 precursor
NM_001401930.1 NP_001388859.1 iduronate 2-sulfatase isoform 4 precursor
NM_001401931.1 NP_001388860.1 iduronate 2-sulfatase isoform 5
NM_001401932.1 NP_001388861.1 iduronate 2-sulfatase isoform 5
NM_001401933.1 NP_001388862.1 iduronate 2-sulfatase isoform 5
NM_001401934.1 NP_001388863.1 iduronate 2-sulfatase isoform 5
NM_001401935.1 NP_001388864.1 iduronate 2-sulfatase isoform 5
NM_001401936.1 NP_001388865.1 iduronate 2-sulfatase isoform 5
NM_001401937.1 NP_001388866.1 iduronate 2-sulfatase isoform 5
NM_010498.4 NP_034628.2 iduronate 2-sulfatase isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables iduronate-2-sulfatase activity IMP
IMP: Inferred from mutant phenotype
12572850 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15962010 MGI
enables sulfuric ester hydrolase activity IDA
IDA: Inferred from direct assay
15962010 MGI
Biological Process GO Annotation Evidence References Source
involved in dermatan sulfate catabolic process IMP
IMP: Inferred from mutant phenotype
30064964 MGI
involved in heparan sulfate proteoglycan catabolic process IMP
IMP: Inferred from mutant phenotype
17876721 MGI
Cellular Component GO Annotation Evidence References Source
is active in lysosomal lumen IDA
IDA: Inferred from direct assay
17876721 MGI
located in lysosome IDA
IDA: Inferred from direct assay
15149955 MGI
is active in lysosome IMP
IMP: Inferred from mutant phenotype
16505002 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

iduronate 2-sulfatase

  • alpha-L-iduronate sulfate sulfatase

  • iduronate sulfatase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-129241 AGX51 Antagonist 99.33% Unkown
HY-RS06545 IDS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18895 Ids Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25386 Ids Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ids NCBI NCBI:3423