Ier3 - immediate early response 3 Gene

Also Known as cI-3; IEX-1; gly96

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15937

Summary

Acts upstream of or within several processes, including intracellular signal transduction; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; and regulation of nucleobase-containing compound metabolic process. Located in nucleus. Is expressed in brain; head; and placenta. Orthologous to human IER3 (immediate early response 3). [provided by Alliance of Genome Resources, Apr 2022]

Ier3 Products (1)

mRNA Protein Name
NM_133662.2 NP_598423.1 radiation-inducible immediate-early gene IEX-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19096392 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
20467439 MGI
acts upstream of glycolytic process IMP
IMP: Inferred from mutant phenotype
19096392 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IDA
IDA: Inferred from direct assay
11753682 MGI
acts upstream of or within mitotic G2 DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
20467439 MGI
acts upstream of or within negative regulation of glycolytic process IMP
IMP: Inferred from mutant phenotype
19096392 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
19923449 MGI
acts upstream of or within negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
IDA: Inferred from direct assay
19096392 MGI
acts upstream of or within negative regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
16166241 MGI
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
19096392 MGI
acts upstream of or within regulation of DNA repair IMP
IMP: Inferred from mutant phenotype
20467439 MGI
acts upstream of or within regulation of nucleocytoplasmic transport IMP
IMP: Inferred from mutant phenotype
20467439 MGI
acts upstream of or within regulation of reactive oxygen species metabolic process IDA
IDA: Inferred from direct assay
19096392 MGI
acts upstream of or within response to protozoan IMP
IMP: Inferred from mutant phenotype
19923449 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
20467439 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

radiation-inducible immediate-early gene IEX-1

  • cAMP inducible gene 3

  • immediate early protein GLY96

  • immediate early response 3 protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06548 IER3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06549 IER3IP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19341 Ier3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25832 Ier3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ier3 NCBI NCBI:8870