Ccn1 - cellular communication network factor 1 Gene

Also Known as Cyr61; Igfbp10

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16007

Summary

Enables extracellular matrix binding activity and Integrin binding activity. Acts upstream of or within several processes, including circulatory system development; positive regulation of hydrolase activity; and regulation of apoptotic process. Located in collagen-containing extracellular matrix. Is expressed in several structures, including brain; cardiovascular system; embryo mesenchyme; sensory organ; and skeleton. Used to study atrial heart septal defect 1 and atrioventricular septal defect. Orthologous to human CCN1 (cellular communication network factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ccn1 Products (2)

mRNA Protein Name
NM_010516.2 NP_034646.1 CCN family member 1 precursor
NM_010516.2 NP_034646.1 CCN family member 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables extracellular matrix binding IDA
IDA: Inferred from direct assay
18757743 MGI
enables integrin binding IDA
IDA: Inferred from direct assay
12826661 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
17023674 MGI
acts upstream of or within apoptotic process involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
17023674 MGI
acts upstream of or within atrial septum morphogenesis IMP
IMP: Inferred from mutant phenotype
17023674 MGI
acts upstream of or within atrioventricular valve morphogenesis IMP
IMP: Inferred from mutant phenotype
17023674 MGI
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
12826661 MGI
acts upstream of or within cell-cell adhesion IDA
IDA: Inferred from direct assay
9441684 MGI
acts upstream of chondroblast differentiation IDA
IDA: Inferred from direct assay
9441684 MGI
acts upstream of or within chondroblast differentiation IDA
IDA: Inferred from direct assay
9441684 MGI
acts upstream of or within chorio-allantoic fusion IMP
IMP: Inferred from mutant phenotype
12446788 MGI
acts upstream of or within extracellular matrix organization IDA
IDA: Inferred from direct assay
18757743 MGI
acts upstream of or within intussusceptive angiogenesis IMP
IMP: Inferred from mutant phenotype
12446788 MGI
acts upstream of or within labyrinthine layer blood vessel development IMP
IMP: Inferred from mutant phenotype
12446788 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17023674 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: Inferred from genetic interaction
16581771 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
19364818 MGI
acts upstream of or within positive regulation of cartilage development IMP
IMP: Inferred from mutant phenotype
9441684 MGI
acts upstream of or within positive regulation of cell differentiation IDA
IDA: Inferred from direct assay
9441684 MGI
acts upstream of or within positive regulation of cell migration IDA
IDA: Inferred from direct assay
16581771 MGI
acts upstream of or within positive regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
18757743 MGI
acts upstream of or within positive regulation of ceramide biosynthetic process IDA
IDA: Inferred from direct assay
19364818 MGI
acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IGI
IGI: Inferred from genetic interaction
19364818 MGI
acts upstream of or within positive regulation of phospholipase activity IDA
IDA: Inferred from direct assay
19364818 MGI
acts upstream of or within reactive oxygen species metabolic process IDA
IDA: Inferred from direct assay
19364818 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
17023674 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CCN family member 1

  • 3CH61

  • IBP-10

  • IGF-binding protein 10

  • IGFBP-10

  • cysteine rich protein 61

  • cysteine-rich angiogenic inducer 61

  • insulin-like growth factor-binding protein 10

  • intermediate early

  • protein CYR61

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02117 CCNA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181537 PROTAC TEAD1/IAP degrader-2 / Unkown
HY-184179 TEAD degrader-1 Degrader / Unkown
HY-RS02110 CCN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11023 PPP3CA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17949 Ccn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18168 Ccna2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24420 Ccn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccn1 NCBI NCBI:3491