Il12rb2 - interleukin 12 receptor, beta 2 Gene

Also Known as Ifnm; IL-12RB2; A930027I18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16162

Summary

Enables protein kinase binding activity. Acts upstream of or within peptidyl-tyrosine phosphorylation; response to cytokine; and response to lipopolysaccharide. Located in external side of plasma membrane. Is expressed in several structures, including brain ventricular layer; genitourinary system; incisor; olfactory epithelium; and submandibular gland. Orthologous to human IL12RB2 (interleukin 12 receptor subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Il12rb2 Products (2)

mRNA Protein Name
NM_001311141.1 NP_001298070.1 interleukin-12 receptor subunit beta-2 isoform 2
NM_008354.4 NP_032380.1 interleukin-12 receptor subunit beta-2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17937931 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
11489994 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
11489994 MGI
acts upstream of or within response to cytokine IMP
IMP: Inferred from mutant phenotype
11489994 MGI
acts upstream of or within response to lipopolysaccharide IGI
IGI: Inferred from genetic interaction
11489994 MGI
acts upstream of or within type II interferon production IGI
IGI: Inferred from genetic interaction
11489994 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
15220916 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-12 receptor subunit beta-2

  • IL-12 receptor subunit beta-2

  • IL-12R subunit beta-2

  • interferon response to microorganisms

Il12rb2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Il12rb2 P97378 Gak Mus musculus Q99KY4
Y2H
17937931
Intra
Il12rb2 P97378 Gak Mus musculus Q99KY4
Anti Tag CoIP
17937931
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Il12rb2 Proteins

Cat. No. Product Name Accession Purity
HY-P72596 IL-12R beta 2 Protein, Mouse (HEK293, Fc) P97378 (N24-N637) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74834 IL-12R beta 2 Protein, Mouse (HEK293, His) P97378 (N24-N637) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06684 IL12RB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22007 Il12rb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28525 Il12rb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990985 Efarindodekin alfa Inhibitor / Unkown
HY-P992042 Anti-IL-12RB2 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il12rb2 NCBI NCBI:3595