Gak - cyclin G associated kinase Gene

Also Known as D130045N16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 231580

About Gak

Chromosome 5: 108,717,277-108,777,621 reverse strand.GRCm39:CM000998.3

This gene has 13 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 7 phenotypes. Ubiquitous expression in colon adult (RPKM 34.6), large intestine adult (RPKM 29.7) and 28 other tissues.

Summary

Predicted to enable clathrin binding activity and cyclin binding activity. Acts upstream of or within several processes, including animal organ development; clathrin coat disassembly; and positive regulation of neural precursor cell proliferation. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Is expressed in several structures, including central nervous system; liver; and retina. Orthologous to human GAK (cyclin G associated kinase). [provided by Alliance of Genome Resources, Apr 2022]

Gak Products (6)

mRNA Protein Name
NM_001359923.1 NP_001346852.1 cyclin-G-associated kinase isoform 5
NM_001282052.1 NP_001268981.1 cyclin-G-associated kinase isoform 3
NM_001359924.1 NP_001346853.1 cyclin-G-associated kinase isoform 2
NM_153569.2 NP_705797.1 cyclin-G-associated kinase isoform 1
NM_001282051.1 NP_001268980.1 cyclin-G-associated kinase isoform 2
NM_001359922.1 NP_001346851.1 cyclin-G-associated kinase isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15752756 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Golgi organization IMP
IMP: Inferred from mutant phenotype
18434600 MGI
acts upstream of or within clathrin coat disassembly IGI
IGI: Inferred from genetic interaction
20160091 MGI
acts upstream of or within clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
18434600 MGI
acts upstream of or within endoplasmic reticulum organization IMP
IMP: Inferred from mutant phenotype
18434600 MGI
acts upstream of or within epidermal cell differentiation IMP
IMP: Inferred from mutant phenotype
18434600 MGI
acts upstream of or within epithelial cell development IMP
IMP: Inferred from mutant phenotype
18434600 MGI
acts upstream of or within establishment of skin barrier IMP
IMP: Inferred from mutant phenotype
18434600 MGI
acts upstream of or within forebrain morphogenesis IMP
IMP: Inferred from mutant phenotype
18434600 MGI
acts upstream of or within intrahepatic bile duct development IMP
IMP: Inferred from mutant phenotype
18434600 MGI
acts upstream of or within keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
18434600 MGI
acts upstream of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
18434600 MGI
acts upstream of or within neuroepithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
18434600 MGI
acts upstream of or within positive regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
18434600 MGI
acts upstream of or within stem cell differentiation IMP
IMP: Inferred from mutant phenotype
18434600 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gak Protein Structure

STKc_GAK

STKc_GAK: cd14036 (38 - 319)

PTP_GAK

PTP_GAK: cd14564 (397 - 559)

PTEN_C2

PTEN_C2: pfam10409 (567 - 705)

PHA03247

PHA03247: cl33720 (712 - 1168)

DnaJ

DnaJ: cd06257 (1252 - 1297)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1305 a.a.
Protein Preferred Names Protein Names

cyclin-G-associated kinase

Gak Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Gak Q99KY4 Il12rb2 Mus musculus P97378
Anti Tag CoIP
17937931
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (40)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-122186 SGC-GAK-1 99.92% Unkown
HY-117626 LP-935509 Inhibitor 99.74% Unkown
HY-153385 TMX1 Degrader 99.57% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-171770 dAurAB5 99.03% Unkown
HY-15800A CZC-25146 Inhibitor 98.05% Unkown
HY-169789 PKN3-IN-1 98.97% Unkown
HY-147219A SIAIS164018 hydrochloride 98.06% Unkown
HY-101290A BMT-090605 hydrochloride Inhibitor 98.76% Unkown
HY-120179 LP-922761 98.21% Unkown
HY-148061 DB1113 99.86% Unkown
HY-155150 JH-XII-03-02 Degrader 99.33% Unkown
HY-124793 GAK inhibitor 49 98.28% Unkown
HY-148062 RSS0680 Degrader 99.85% Unkown
HY-179717 WZS0347 Degrader 99.06% Unkown
HY-135871 BMT-124110 99.15% Unkown
HY-148063 DB0614 99.92% Unkown
HY-147761 GAK inhibitor 2 Inhibitor 98.58% Unkown
HY-120179A LP-922761 hydrate 98.0% Unkown
HY-124793A GAK inhibitor 49 hydrochloride 99.52% Unkown
HY-135871A BMT-124110 formic Inhibitor / Unkown
HY-147219 SIAIS164018 / Unkown
HY-181293 PROTAC AAK1 degrader-1 Degrader / Unkown
HY-101290 BMT-090605 Inhibitor 98.27% Unkown
HY-125142 AP-24567 / Unkown
HY-150782 UNC-CA359 Inhibitor / Unkown
HY-159174 EPHA2/A4/GAK-IN-1 Inhibitor / Unkown
HY-183098 UNC8209 / Unkown
HY-183100 UNC8461 Control / Unkown
HY-184580 KMG-732 Inhibitor / Unkown
HY-P4443 Ac-GAK-AMC / Unkown
HY-RS05235 GAK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05236 Gak Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05237 Gak Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-15800 CZC-25146 hydrochloride Inhibitor / Unkown
HY-174213 AAK1-IN-7 Inhibitor / Unkown
HY-174214 AAK1-IN-8 Inhibitor / Unkown
HY-181169 GAK-IN-3 Inhibitor / Unkown
HY-184096 Forazapadin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gak NCBI NCBI:2580