Itga7 - integrin alpha 7 Gene

Also Known as [a]7; alpha7

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16404

Summary

This gene encodes a member of the Integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and Other cells. The encoded transmembrane protein is the alpha subunit that forms a noncovalent heterodimer with the beta subunit to form the functional Integrin receptor that binds to laminin. Mice lacking the encoded protein exhibit symptoms of progressive muscular dystrophy, impaired axonal regeneration and cerebral vascular defects. [provided by RefSeq, Aug 2016]

Itga7 Products (5)

mRNA Protein Name
NM_001330160.2 NP_001317089.1 integrin alpha-7 isoform 2 precursor
NM_001406285.1 NP_001393214.1 integrin alpha-7 isoform 3
NM_001406286.1 NP_001393215.1 integrin alpha-7 isoform 4
NM_001406287.1 NP_001393216.1 integrin alpha-7 isoform 5
NM_008398.3 NP_032424.2 integrin alpha-7 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to laminin binding IDA
IDA: Inferred from direct assay
1839357 MGI
contributes to laminin binding IMP
IMP: Inferred from mutant phenotype
9004048 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17403664 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
16003770 MGI
acts upstream of or within cell adhesion IMP
IMP: Inferred from mutant phenotype
9004048 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
9004048 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19796622 MGI
part of integrin alpha7-beta1 complex IDA
IDA: Inferred from direct assay
18611855 MGI
part of integrin alpha7-beta1 complex IPI
IPI: Inferred from physical interaction
1839357 MGI
located in muscle tendon junction IDA
IDA: Inferred from direct assay
18611855 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
18611855 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
18611855 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06954 ITGA7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20969 Itga7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27486 Itga7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itga7 NCBI NCBI:3679