Lep - leptin Gene

Also Known as ob; obese

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16846

Summary

Enables DNA binding activity and growth factor activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Acts upstream of or within several processes, including Insulin secretion; monocarboxylic acid metabolic process; and regulation of Insulin secretion. Located in cytoplasm and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; early conceptus; and genitourinary system. Used to study abdominal obesity-metabolic syndrome (multiple); fatty liver disease (multiple); obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital Leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (Leptin). [provided by Alliance of Genome Resources, Apr 2022]

Lep Products (1)

mRNA Protein Name
NM_008493.3 NP_032519.1 leptin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
29519872 MGI
enables hormone activity IDA
IDA: Inferred from direct assay
36977414 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24882746 MGI
Biological Process GO Annotation Evidence References Source
involved in T cell differentiation IMP
IMP: Inferred from mutant phenotype
9732873 MGI
acts upstream of or within adipose tissue development IGI
IGI: Inferred from genetic interaction
10742101 MGI
involved in adult feeding behavior IDA
IDA: Inferred from direct assay
9590691 MGI
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
23413430 MGI
acts upstream of or within bile acid metabolic process IDA
IDA: Inferred from direct assay
12114517 MGI
involved in bone growth IMP
IMP: Inferred from mutant phenotype
10660043 MGI
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
21234744 MGI
acts upstream of or within cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
29519872 MGI
acts upstream of or within central nervous system neuron development IMP
IMP: Inferred from mutant phenotype
10592285 MGI
acts upstream of or within cholesterol metabolic process IGI
IGI: Inferred from genetic interaction
15995171 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: Inferred from genetic interaction
28069950 MGI
acts upstream of or within eating behavior IGI
IGI: Inferred from genetic interaction
10802666 MGI
acts upstream of or within elastin metabolic process IMP
IMP: Inferred from mutant phenotype
23413430 MGI
involved in energy homeostasis IDA
IDA: Inferred from direct assay
36977414 MGI
acts upstream of or within fatty acid beta-oxidation IGI
IGI: Inferred from genetic interaction
22958918 MGI
acts upstream of or within glucose homeostasis IGI
IGI: Inferred from genetic interaction
22958918 MGI
acts upstream of or within glucose metabolic process IMP
IMP: Inferred from mutant phenotype
12540600 MGI
acts upstream of or within hormone metabolic process IMP
IMP: Inferred from mutant phenotype
16513828 MGI
acts upstream of or within insulin secretion IGI
IGI: Inferred from genetic interaction
16141392 MGI
involved in leptin-mediated signaling pathway IDA
IDA: Inferred from direct assay
16825198 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
12815040 MGI
involved in negative regulation of appetite IDA
IDA: Inferred from direct assay
9590691 MGI
involved in negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
25060689 MGI
involved in negative regulation of glucagon secretion IDA
IDA: Inferred from direct assay
21234744 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21234744 MGI
involved in phagocytosis IDA
IDA: Inferred from direct assay
9438411 MGI
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
16825198 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
27986616 MGI
involved in positive regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
9438411 MGI
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
9438411 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
16825198 MGI
involved in positive regulation of protein import into nucleus IDA
IDA: Inferred from direct assay
21234744 MGI
involved in positive regulation of receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
16825198 MGI
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
9438411 MGI
involved in regulation of bone remodeling IMP
IMP: Inferred from mutant phenotype
10660043 MGI
involved in regulation of brown fat cell differentiation IDA
IDA: Inferred from direct assay
20620997 MGI
acts upstream of or within regulation of catalytic activity IMP
IMP: Inferred from mutant phenotype
23413430 MGI
involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
16825198 MGI
acts upstream of or within regulation of fat cell differentiation IGI
IGI: Inferred from genetic interaction
22927639 MGI
acts upstream of or within regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
16513828 MGI
acts upstream of or within regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
16513828 MGI
acts upstream of or within regulation of intestinal cholesterol absorption IDA
IDA: Inferred from direct assay
12114517 MGI
acts upstream of or within regulation of lipid biosynthetic process IGI
IGI: Inferred from genetic interaction
28069950 MGI
acts upstream of or within regulation of metabolic process IMP
IMP: Inferred from mutant phenotype
12925742 MGI
involved in regulation of nitric-oxide synthase activity IDA
IDA: Inferred from direct assay
15899045 MGI
acts upstream of or within regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
20541607 MGI
acts upstream of or within regulation of steroid biosynthetic process IMP
IMP: Inferred from mutant phenotype
16513828 MGI
acts upstream of or within response to dietary excess IGI
IGI: Inferred from genetic interaction
12177191 MGI
acts upstream of or within response to dietary excess IMP
IMP: Inferred from mutant phenotype
16141392 MGI
acts upstream of or within response to insulin IMP
IMP: Inferred from mutant phenotype
16141392 MGI
involved in sexual reproduction IMP
IMP: Inferred from mutant phenotype
8589726 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11387233 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
9590691 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leptin

  • obesity factor

Recombinant Lep Proteins

Cat. No. Product Name Accession Purity
HY-P70704 Leptin Protein, Mouse Q544U0 (V22-C167) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70704A Leptin Protein, Mouse (His) Q544U0 (V22-C167) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07593 LEP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17798 Lep Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24266 Lep Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lep NCBI NCBI:3952