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Lipa - lysosomal acid lipase A Gene

Also Known as Lal; Lip1; Lip-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16889

Summary

Predicted to enable sterol esterase activity. Acts upstream of or within several processes, including homeostasis of number of cells within a tissue; lung development; and tissue remodeling. Predicted to be located in cytosol; lysosome; and nuclear lumen. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including adrenal cortex zone; alimentary system; brain; hemolymphoid system; and metanephros. Used to study Wolman disease and lysosomal and Lipase deficiency. Human ortholog(s) of this gene implicated in Wolman disease; Cholesterol ester storage disease; and lysosomal and Lipase deficiency. Orthologous to human LIPA (Lipase A, lysosomal acid type). [provided by Alliance of Genome Resources, Apr 2022]

Lipa Products (2)

mRNA	Protein	Name
NM_001111100.1	NP_001104570.1	lysosomal acid lipase/cholesteryl ester hydrolase precursor
NM_021460.3	NP_067435.3	lysosomal acid lipase/cholesteryl ester hydrolase precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	24287405	MGI
acts upstream of or within T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19179613	MGI
acts upstream of or within T cell differentiation	IMP IMP: Inferred from mutant phenotype	19179613	MGI
acts upstream of or within T cell proliferation	IMP IMP: Inferred from mutant phenotype	19179613	MGI
acts upstream of or within TOR signaling	IMP IMP: Inferred from mutant phenotype	22383970	MGI
acts upstream of or within acute inflammatory response	IMP IMP: Inferred from mutant phenotype	28402950	MGI
acts upstream of or within adaptive thermogenesis	IMP IMP: Inferred from mutant phenotype	29374543	MGI
acts upstream of or within adipose tissue development	IMP IMP: Inferred from mutant phenotype	29374543	MGI
acts upstream of or within blood vessel endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	33357458	MGI
acts upstream of or within bone marrow development	IMP IMP: Inferred from mutant phenotype	20348241	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	14644759	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	22383970	MGI
acts upstream of or within cell proliferation in bone marrow	IMP IMP: Inferred from mutant phenotype	20348241	MGI
acts upstream of or within cellular lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	28402950	MGI
acts upstream of or within cellular lipid metabolic process	IMP IMP: Inferred from mutant phenotype	28402950	MGI
acts upstream of or within cholesterol biosynthetic process	IMP IMP: Inferred from mutant phenotype	25147230	MGI
acts upstream of or within cholesterol efflux	IMP IMP: Inferred from mutant phenotype	29599133	MGI
acts upstream of or within cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	24370824	MGI
acts upstream of or within cholesterol storage	IGI IGI: Inferred from genetic interaction	25450374	MGI
acts upstream of or within cholesterol storage	IMP IMP: Inferred from mutant phenotype	24370824	MGI
acts upstream of or within cholesterol transport	IMP IMP: Inferred from mutant phenotype	29599133	MGI
acts upstream of or within common myeloid progenitor cell proliferation	IMP IMP: Inferred from mutant phenotype	24287405	MGI
acts upstream of or within cytokine production	IMP IMP: Inferred from mutant phenotype	14644759	MGI
acts upstream of or within defecation	IMP IMP: Inferred from mutant phenotype	25147230	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	25147230	MGI
acts upstream of or within endocytosis	IMP IMP: Inferred from mutant phenotype	33357458	MGI
acts upstream of or within endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	33357458	MGI
acts upstream of or within endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	33357458	MGI
acts upstream of or within energy homeostasis	IMP IMP: Inferred from mutant phenotype	30639734	MGI
acts upstream of or within epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	14644759	MGI
acts upstream of or within fat cell proliferation	IMP IMP: Inferred from mutant phenotype	33357458	MGI
acts upstream of or within fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	29374543	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	19179613	MGI
acts upstream of or within glucose metabolic process	IMP IMP: Inferred from mutant phenotype	30639734	MGI
acts upstream of or within glycolytic process	IMP IMP: Inferred from mutant phenotype	25807535	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	20348241	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	20348241	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	33159889	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	14644759	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	14644759	MGI
acts upstream of or within lipid homeostasis	IMP IMP: Inferred from mutant phenotype	30639734	MGI
acts upstream of or within lipid import into cell	IMP IMP: Inferred from mutant phenotype	29374543	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	25147230	MGI
acts upstream of or within lipid storage	IMP IMP: Inferred from mutant phenotype	31023823	MGI
acts upstream of or within lipoprotein catabolic process	IMP IMP: Inferred from mutant phenotype	33357458	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	24370824	MGI
acts upstream of or within liver morphogenesis	IMP IMP: Inferred from mutant phenotype	24370824	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	14644759	MGI
acts upstream of or within lysosome organization	IMP IMP: Inferred from mutant phenotype	25807535	MGI
acts upstream of or within macrophage homeostasis	IMP IMP: Inferred from mutant phenotype	14644759	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	25807535	MGI
acts upstream of or within mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	22383970	MGI
acts upstream of or within multicellular organismal-level chemical homeostasis	IMP IMP: Inferred from mutant phenotype	27354281	MGI
acts upstream of or within multicellular organismal-level homeostasis	IMP IMP: Inferred from mutant phenotype	19179613	MGI
acts upstream of or within myeloid cell apoptotic process	IMP IMP: Inferred from mutant phenotype	20348241	MGI
acts upstream of or within myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	20348241	MGI
acts upstream of or within neutral lipid metabolic process	IMP IMP: Inferred from mutant phenotype	19179613	MGI
acts upstream of or within positive regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19179613	MGI
acts upstream of or within programmed cell death	IMP IMP: Inferred from mutant phenotype	21697390	MGI
acts upstream of or within reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	24287405	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	25807535	MGI
acts upstream of or within regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	24287405	MGI
acts upstream of or within respiratory burst involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	25807535	MGI
acts upstream of or within response to cold	IMP IMP: Inferred from mutant phenotype	29374543	MGI
acts upstream of or within response to dietary excess	IMP IMP: Inferred from mutant phenotype	30639734	MGI
acts upstream of or within response to lipid	IMP IMP: Inferred from mutant phenotype	29599133	MGI
acts upstream of or within response to rapamycin	IMP IMP: Inferred from mutant phenotype	25807535	MGI
acts upstream of or within response to vitamin A	IMP IMP: Inferred from mutant phenotype	31023823	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	24370824	MGI
acts upstream of or within retinoid metabolic process	IMP IMP: Inferred from mutant phenotype	27354281	MGI
acts upstream of or within small GTPase-mediated signal transduction	IMP IMP: Inferred from mutant phenotype	22383970	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	19179613	MGI
acts upstream of or within sterol metabolic process	IMP IMP: Inferred from mutant phenotype	21289032	MGI
acts upstream of or within tissue remodeling	IMP IMP: Inferred from mutant phenotype	14644759	MGI
acts upstream of or within triglyceride metabolic process	IMP IMP: Inferred from mutant phenotype	30639734	MGI
acts upstream of or within triglyceride-rich lipoprotein particle clearance	IMP IMP: Inferred from mutant phenotype	33357458	MGI
acts upstream of or within vitamin A metabolic process	IMP IMP: Inferred from mutant phenotype	27354281	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in lysosome	IDA IDA: Inferred from direct assay	21289032	MGI
is active in lysosome	IMP IMP: Inferred from mutant phenotype	28402950	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
lysosomal acid lipase/cholesteryl ester hydrolase	acid cholesteryl ester hydrolase cholesteryl esterase lipase A lysosomal acid lipase 1 sterol esterase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148755	ERX-41		98.25%	Unkown
HY-147149	BPN-15477	Modulator	99.92%	Unkown
HY-RS17291	Lipa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181986	ERX-208	Inducer	/	Unkown
HY-RS02454	CEL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07684	LIPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23746	Lipa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lipa	NCBI	NCBI:3988