Lmo2 - LIM domain only 2 Gene

Also Known as Ttg2; Rbtn2; Rbtn-2; Rhom-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16909

Summary

Enables chromatin binding activity. Contributes to DNA binding activity. Involved in negative regulation of erythrocyte differentiation. Acts upstream of or within embryonic hemopoiesis and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study acute lymphoblastic leukemia. Orthologous to human LMO2 (LIM domain only 2). [provided by Alliance of Genome Resources, Apr 2022]

Lmo2 Products (4)

mRNA Protein Name
NM_001142335.1 NP_001135807.1 rhombotin-2 isoform 2
NM_001142336.1 NP_001135808.1 rhombotin-2 isoform 3
NM_001142337.1 NP_001135809.1 rhombotin-2 isoform 3
NM_008505.4 NP_032531.2 rhombotin-2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to DNA binding IDA
IDA: Inferred from direct assay
9391090 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
18184866 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7568177 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
9860983 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within embryonic hemopoiesis IGI
IGI: Inferred from genetic interaction
10631184 MGI
involved in negative regulation of erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
9391090 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
18184866 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9391090 MGI
part of protein-containing complex IPI
IPI: Inferred from physical interaction
9391090 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rhombotin-2

  • LIM domain only protein 2

  • LIM only 2

  • LMO-2

  • T-cell translocation protein 2

  • cysteine-rich protein TTG-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07718 LMO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21367 Lmo2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27886 Lmo2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lmo2 NCBI NCBI:4005