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OIT3 - oncoprotein induced transcript 3 Gene

Also Known as LZP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 170392

About OIT3

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:72,893,739-72,933,036 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues and 5 paralogues. Biased expression in liver (RPKM 29.6), small intestine (RPKM 2.8) and 3 other tissues.

Summary

This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016]

OIT3 Products (1)

mRNA	Protein	Name
NM_152635.3	NP_689848.1	oncoprotein-induced transcript 3 protein precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OIT3 Protein Structure

FXa_inhibition

Zona_pellucida

0
100
200
300
400
500
545 a.a.

Protein Preferred Names	Protein Names
oncoprotein-induced transcript 3 protein	liver-specific ZP domain-containing protein

OIT3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OIT3	Q8WWZ8	KRTAP11-1	Homo sapiens	Q8IUC1	Validated Y2H	32296183
Intra	OIT3	Q8WWZ8	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	OIT3	Q8WWZ8	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	OIT3	Q8WWZ8	LCE1F	Homo sapiens	Q5T754	Y2H Prey Pooling	32296183
Intra	OIT3	Q8WWZ8	LCE1F	Homo sapiens	Q5T754	Validated Y2H	32296183
Intra	OIT3	Q8WWZ8	LCE1F	Homo sapiens	Q5T754	Y2H Array	32296183
Intra	OIT3	Q8WWZ8	LCE1C	Homo sapiens	Q5T751	Y2H Prey Pooling	32296183
Intra	OIT3	Q8WWZ8	LCE1C	Homo sapiens	Q5T751	Validated Y2H	32296183
Intra	OIT3	Q8WWZ8	LCE1C	Homo sapiens	Q5T751	Y2H Array	32296183
Intra	OIT3	Q8WWZ8	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	OIT3	Q8WWZ8	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	OIT3	Q8WWZ8	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	OIT3	Q8WWZ8	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	OIT3	Q8WWZ8	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	OIT3	Q8WWZ8	VAC14	Homo sapiens	Q08AM6	Validated Y2H	32296183
Intra	OIT3	Q8WWZ8	CRCT1	Homo sapiens	Q9UGL9	Validated Y2H	32296183
Intra	OIT3	Q8WWZ8	CRCT1	Homo sapiens	Q9UGL9	Y2H Prey Pooling	32296183
Intra	OIT3	Q8WWZ8	CRCT1	Homo sapiens	Q9UGL9	Y2H Array	32296183
Intra	OIT3	Q8WWZ8	FBXO34	Homo sapiens	Q9NWN3	Validated Y2H	32296183
Intra	OIT3	Q8WWZ8	FBXO34	Homo sapiens	Q9NWN3	Y2H Array	32296183
Intra	OIT3	Q8WWZ8	FBXO34	Homo sapiens	Q9NWN3	Y2H Prey Pooling	32296183
Intra	OIT3	Q8WWZ8	OTX1	Homo sapiens	P32242	Y2H Prey Pooling	32296183
Intra	OIT3	Q8WWZ8	OTX1	Homo sapiens	P32242	Validated Y2H	32296183
Intra	OIT3	Q8WWZ8	OTX1	Homo sapiens	P32242	Y2H Array	32296183
Intra	OIT3	Q8WWZ8	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	OIT3	Q8WWZ8	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	OIT3	Q8WWZ8	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	OIT3	Q8WWZ8	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	OIT3	Q8WWZ8	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	OIT3	Q8WWZ8	LCE3A	Homo sapiens	Q5TA76	Validated Y2H	32296183
Intra	OIT3	Q8WWZ8	LCE3A	Homo sapiens	Q5TA76	Y2H Array	32296183
Intra	OIT3	Q8WWZ8	LCE3A	Homo sapiens	Q5TA76	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09767	OIT3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21398	Oit3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27917	Oit3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OIT3	MGD	MGI:1201782
Macaca mulatta	OIT3	VGNC	VGNC:75492
Bos taurus	OIT3	VGNC	VGNC:58354
Rattus norvegicus	OIT3	RGD	RGD:735082
Felis catus	OIT3	VGNC	VGNC:63957
Others	OIT3	NCBI