Map2k1 - mitogen activated protein kinase kinase 1 Gene

Also Known as Mek1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170851

About Map2k1

Primary_assembly 8: 64,683,449-64,755,147 reverse strand.mRatBN7.2:CM026981.1

This gene has 5 transcripts (splice variants), 211 orthologues, 8 paralogues and is associated with 38 phenotypes. Biased expression in Brain (RPKM 58.), Muscle (RPKM 31.3) and 9 other tissues.

Summary

Enables ATP binding activity; MAP kinase kinase activity; and enzyme binding activity. Involved in several processes, including establishment of vesicle localization; regulation of gene expression; and regulation of intracellular signal transduction. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with microtubule. Used to study cataract and prostate adenocarcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Map2k1 Products (1)

mRNA Protein Name
NM_031643.4 NP_113831.1 dual specificity mitogen-activated protein kinase kinase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
7611406 RGD
enables MAP kinase kinase activity IDA
IDA: Inferred from direct assay
7611406 RGD
enables mitogen-activated protein kinase kinase kinase binding IDA
IDA: Inferred from direct assay
7565670 RGD
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: Inferred from physical interaction
16006144 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16272159 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
15917294 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15917294 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
7935430 RGD
Biological Process GO Annotation Evidence References Source
involved in Golgi inheritance IMP
IMP: Inferred from mutant phenotype
9458043 RGD
involved in melanosome transport IDA
IDA: Inferred from direct assay
15753041 RGD
involved in negative regulation of gene expression IGI
IGI: Inferred from genetic interaction
28947594 RGD
involved in negative regulation of homotypic cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
17183546 RGD
involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
15459207 RGD
involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
15459207 RGD
involved in neuron differentiation IMP
IMP: Inferred from mutant phenotype
17202850 RGD
involved in neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
17202850 RGD
involved in positive regulation of ATP biosynthetic process IGI
IGI: Inferred from genetic interaction
15459207 RGD
involved in positive regulation of ATP biosynthetic process IMP
IMP: Inferred from mutant phenotype
15459207 RGD
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
17183546 RGD
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
7935430 RGD
acts upstream of or within positive regulation of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
19029245 RGD
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
26581593 RGD
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
17183546 RGD
involved in positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
15459207 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
15459207 RGD
involved in positive regulation of muscle contraction IGI
IGI: Inferred from genetic interaction
15459207 RGD
involved in positive regulation of muscle contraction IMP
IMP: Inferred from mutant phenotype
15459207 RGD
involved in positive regulation of transcription elongation by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18086894 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
7565670 RGD
involved in regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
26581593 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane EXP
EXP: Inferred from Experiment
12202034 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
12202034 RGD
involved in regulation of vascular associated smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
10198244 RGD
involved in response to axon injury IMP
IMP: Inferred from mutant phenotype
15737734 RGD
involved in response to glucocorticoid IDA
IDA: Inferred from direct assay
11872750 RGD
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
16481589 RGD
involved in triglyceride homeostasis IDA
IDA: Inferred from direct assay
26581593 RGD
involved in vesicle transport along microtubule IDA
IDA: Inferred from direct assay
15753041 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
9714150 RGD
located in cell cortex IDA
IDA: Inferred from direct assay
16272159 RGD
located in dendrite IDA
IDA: Inferred from direct assay
10465442 RGD
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
9714150 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
12202034 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12202034 RGD
located in microtubule IDA
IDA: Inferred from direct assay
10465442 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
9714150 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12876277 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
7478291 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map2k1 Protein Structure

PKc_MEK1

PKc_MEK1: cd06650 (61 - 379)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 1

  • ERK activator kinase 1

  • MAP kinase kinase 1

  • MAP kinase/Erk kinase 1

  • MAPK/ERK kinase 1

  • MAPKK 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-184145 AKT1-IN-13 / Unkown
HY-E70842 MAP2K1 L115P Recombinant Human Active Protein Kinase / Unkown
HY-E70843 MAP2K1 P124L Recombinant Human Active Protein Kinase / Unkown
HY-RS08033 MAP2K1 Human Pre-designed siRNA Set A / Unkown
HY-RS08034 Map2k1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08035 Map2k1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2k1 NCBI NCBI:5604