Mc4r - melanocortin 4 receptor Gene

Mus musculus

Also known as Pkcp; Mc4-r

Gene ID: 17202 | Gene type: protein coding

About Mc4r

Chromosome 18: 66,990,775-66,993,577 reverse strand.GRCm39:CM001011.3

This gene has 1 transcript (splice variant), 231 orthologues, 18 paralogues and is associated with 44 phenotypes.

Summary

This gene encodes a member of the Melanocortin Receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide Hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis. Disruption of this gene promotes hyperphagia and obesity, and is associated with increased Cholesterol levels and Insulin resistance. [provided by RefSeq, Dec 2012]

Mc4r Products(1)

mRNA	Protein	Name
NM_016977.4	NP_058673.2	melanocortin receptor 4

Mc4r Protein Structure

7tmA_MC4R

0
100
200
300
332 a.a.

Protein Preferred Names

Protein Names

melanocortin receptor 4

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-118930	MK-0493	Agonist	99.02%	Phase 2

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0252	α-MSH	Agonist	99.57%	Unkown
HY-P0227	SHU 9119		99.95%	Unkown
HY-P0097A	Nonapeptide-1 acetate salt	Antagonist	98.70%	Unkown
HY-P0252A	α-MSH TFA	Agonist	98.79%	Unkown
HY-10624	THIQ	Agonist	98.11%	Unkown
HY-P1215A	HS024 TFA	Antagonist	99.80%	Unkown
HY-P1216A	HS014 TFA	Antagonist	99.87%	Unkown
HY-110123	ML-00253764 hydrochloride	Inhibitor	99.47%	Unkown
HY-P2242A	RO27-3225 TFA	Agonist	98.94%	Unkown
HY-P1213	JKC363	Antagonist	99.55%	Unkown
HY-P1216	HS014	Antagonist	/	Unkown
HY-P0252B	α-MSH free acid	Agonist	/	Unkown
HY-P1213A	JKC363 TFA	Antagonist	/	Unkown
HY-P0097	Nonapeptide-1	Antagonist	/	Unkown
HY-P3561	Agouti-related Protein (AGRP) (83-132) Amide (human)	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mc4r	NCBI	NCBI:4160

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