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Mdm2 - transformed mouse 3T3 cell double minute 2 Gene

Also Known as Mdm-2; 1700007J15Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17246

About Mdm2

Chromosome 10: 117,524,780-117,546,663 reverse strand.GRCm39:CM001003.3

This gene has 9 transcripts (splice variants), 247 orthologues, 1 paralogue and is associated with 56 phenotypes. Ubiquitous expression in testis adult (RPKM 1.8), CNS E11.5 (RPKM 9.8) and 28 other tissues.

Summary

Enables p53 binding activity and ubiquitin protein Ligase activity. Involved in apoptotic process and positive regulation of muscle cell differentiation. Acts upstream of or within several processes, including blood vessel remodeling; circulatory system development; and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland Cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Mdm2 Products (2)

mRNA	Protein	Name
NM_010786.4	NP_034916.1	E3 ubiquitin-protein ligase Mdm2 isoform 1
NM_001288586.2	NP_001275515.1	E3 ubiquitin-protein ligase Mdm2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables p53 binding	IPI IPI: Inferred from physical interaction	15678128	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10906133	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	12145204	MGI
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	17591690	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic process	IDA IDA: Inferred from direct assay	30879903	MGI
acts upstream of or within atrial septum development	IGI IGI: Inferred from genetic interaction	22821713	MGI
acts upstream of or within atrioventricular valve morphogenesis	IGI IGI: Inferred from genetic interaction	22821713	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	22821713	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	22821713	MGI
acts upstream of or within cardiac septum morphogenesis	IGI IGI: Inferred from genetic interaction	22821713	MGI
acts upstream of cell cycle	IGI IGI: Inferred from genetic interaction	15485902	MGI
acts upstream of or within endocardial cushion morphogenesis	IGI IGI: Inferred from genetic interaction	22821713	MGI
acts upstream of or within endocardial cushion morphogenesis	IMP IMP: Inferred from mutant phenotype	22821713	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	22821713	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	22821713	MGI
acts upstream of or within heart valve development	IGI IGI: Inferred from genetic interaction	22821713	MGI
acts upstream of or within positive regulation of cell cycle	IGI IGI: Inferred from genetic interaction	15485902	MGI
involved in positive regulation of muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	25720496	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22821713	MGI
acts upstream of or within regulation of heart rate	IGI IGI: Inferred from genetic interaction	22821713	MGI
acts upstream of or within traversing start control point of mitotic cell cycle	IDA IDA: Inferred from direct assay	10906133	MGI
acts upstream of or within ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	12145204	MGI
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	25720496	MGI
acts upstream of or within ventricular septum development	IGI IGI: Inferred from genetic interaction	22821713	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14767071	MGI
located in nucleolus	IDA IDA: Inferred from direct assay	11718560	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11718560	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mdm2 Protein Structure

MDM2

zf-RanBP

mRING-HC-C2H2C4_MDM2

0
100
200
300
400
489 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase Mdm2	RING-type E3 ubiquitin transferase Mdm2 double minute 2 protein oncoprotein Mdm2 p53-binding protein Mdm2

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0004	Oridonin		99.89%	Phase 4

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130684	MDM2 ligand 5		98.02%	Unkown
HY-128837	Nutlin carboxylic acid		98.63%	Unkown
HY-P5930	HOXB7 8–25		/	Unkown
HY-128837A	(rel)-Nutlin carboxylic acid		/	Unkown
HY-128836	(4R,5S)-Nutlin carboxylic acid		/	Unkown
HY-168280	AS1411-C4-VH032	Degrader	/	Unkown
HY-148106	MEL23	Inhibitor	/	Unkown
HY-181813	PROTAC DHFR Degrader-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mdm2	NCBI	NCBI:4193