Mdm2 - transformed mouse 3T3 cell double minute 2 Gene

Mus musculus

Also known as Mdm-2; 1700007J15Rik

Gene ID: 17246 | Gene type: protein coding

About Mdm2

Chromosome 10: 117,524,780-117,546,663 reverse strand.GRCm39:CM001003.3

This gene has 9 transcripts (splice variants), 247 orthologues, 1 paralogue and is associated with 56 phenotypes. Ubiquitous expression in testis adult (RPKM 1.8), CNS E11.5 (RPKM 9.8) and 28 other tissues.

Summary

Enables p53 binding activity and ubiquitin protein ligase activity. Involved in apoptotic process and positive regulation of muscle cell differentiation. Acts upstream of or within several processes, including blood vessel remodeling; circulatory system development; and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland Cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Mdm2 Products(2)

mRNA	Protein	Name
NM_010786.4	NP_034916.1	E3 ubiquitin-protein ligase Mdm2 isoform 1
NM_001288586.2	NP_001275515.1	E3 ubiquitin-protein ligase Mdm2 isoform 2

Mdm2 Protein Structure

MDM2

zf-RanBP

mRING-HC-C2H2C4_MDM2

0
100
200
300
400
489 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase Mdm2

RING-type E3 ubiquitin transferase Mdm2	double minute 2 protein
oncoprotein Mdm2	p53-binding protein Mdm2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128837	Nutlin carboxylic acid		98.36%	Unkown
HY-128836	(4R,5S)-Nutlin carboxylic acid		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mdm2	NCBI	NCBI:4193

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