Me1 - malic enzyme 1, NADP(+)-dependent, cytosolic Gene

Also Known as Mod1; Mdh-1; Mod-1; D9Ertd267e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17436

Summary

Enables malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in carboxylic acid metabolic process; regulation of NADP metabolic process; and response to hormone. Located in mitochondrion. Is expressed in several structures, including cardiovascular system; central nervous system; cranium; eye; and genitourinary system. Orthologous to human ME1 (malic enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]

Me1 Products (2)

mRNA Protein Name
NM_001198933.1 NP_001185862.1 NADP-dependent malic enzyme isoform 2
NM_008615.2 NP_032641.2 NADP-dependent malic enzyme isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
IDA: Inferred from direct assay
6838491 MGI
enables malate dehydrogenase (decarboxylating) (NADP+) activity IMP
IMP: Inferred from mutant phenotype
18802677 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23055941 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NADP-dependent malic enzyme

  • NADP-ME

  • malic enzyme, supernatant

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99595 Sirtratumab vedotin 97.38% Phase 1
HY-172661 Kylo-0603 / Phase 1

Pre-clinical Phase

Bioactive Molecules (29)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15227 EPZ004777 99.74% Unkown
HY-124861 Malic enzyme inhibitor ME1 Inhibitor 99.69% Unkown
HY-403538 iZMYND8-34 Inhibitor 98.89% Unkown
HY-150621 AS1134900 Activator 98.87% Unkown
HY-15227A EPZ004777 hydrochloride 98.92% Unkown
HY-149677 ZK53 99.19% Unkown
HY-149091 KDM5B-IN-4 Inhibitor 99.68% Unkown
HY-128912 Arborinine Inhibitor 99.87% Unkown
HY-149213 LSD1/TLK1-IN-1 99.20% Unkown
HY-P2254 H3K27(Me3) (15-34) 96.97% Unkown
HY-P2255 H3K4(Me) (1-20) 99.87% Unkown
HY-RS08270 ME1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-115619 EPZ004777 formate / Unkown
HY-124961 LSD1-IN-2 Inhibitor / Unkown
HY-158436 Antitumor agent-155 / Unkown
HY-164144 EPZ033294 Inhibitor 98.41% Unkown
HY-168086 LSD1-IN-35 Inhibitor / Unkown
HY-174450 KMT9-IN-1 Inhibitor / Unkown
HY-176283 Tubulin/LSD1-IN-1 / Unkown
HY-181781 LSD1-IN-48 / Unkown
HY-181849 MS2928 Inhibitor / Unkown
HY-182054 Topoisomerase ll/ME-1-IN-1 / Unkown
HY-P10819 S9-CMC1 TFA / Unkown
HY-P2252 H3K27(Me) (15-34) / Unkown
HY-P2253 H3K27(Me2) (15-34) / Unkown
HY-RS10137 PCDHB16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17185 Me1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21063 Tcf12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23636 Me1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991080 Anti-SLC44A4 Antibody ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Me1 NCBI NCBI:4199