LSD1-IN-51
LSD1-IN-51 is a selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 value of 8.7 nM. LSD1-IN-51 selectively inhibits H3K4me1/2 demethylation by binding to the FAD domain of LSD1, while disrupting the interaction between LSD1 and multiprotein complexes such as HDAC1/2 and CoREST. LSD1-IN-51 can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1423715-30-3
- Formula: C16H16ClN3O4S
- Molecular Weight:381.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
LSD1 8.7 nM (IC50) |
In Vitro
LSD1-IN-51 (Compound 29) potently inhibits LSD1 enzymatic activity in a cell-free biochemical assay system in vitro at 60 min, with an IC50 value of 8.7 nM[1].
LSD1-IN-51 (96 h) exhibits no significant cell growth inhibitory effect or heme oxygenase-1 (HMOX1) gene transcriptional induction activity in T-47D breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1423715-30-3
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Molecular Weight 381.83
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Formula C16H16ClN3O4S
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SMILES
C(N/N=C(\C)/C1=C(O)C=CC(Cl)=C1)(=O)C2=CC(S(NC)(=O)=O)=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LSD1-IN-51 Related Classifications
HY-187092 Related Classifications
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