country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-187092

Copy Link Print Information

LSD1-IN-51

LSD1-IN-51 is a selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC₅₀ value of 8.7 nM. LSD1-IN-51 selectively inhibits H3K4me1/2 demethylation by binding to the FAD domain of LSD1, while disrupting the interaction between LSD1 and multiprotein complexes such as HDAC1/2 and CoREST. LSD1-IN-51 can be used for cancer research.

For research use only. We do not sell to patients.

CAS No.: 1423715-30-3
Formula: C₁₆H₁₆ClN₃O₄S
Molecular Weight:381.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LSD1-IN-51 Chemical Structure

CAS No.: 1423715-30-3

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

LSD1

8.7 nM (IC₅₀)

All Histone Demethylase Isoforms :

In Vitro

LSD1-IN-51 (Compound 29) potently inhibits LSD1 enzymatic activity in a cell-free biochemical assay system in vitro at 60 min, with an IC50 value of 8.7 nM^[1].
LSD1-IN-51 (96 h) exhibits no significant cell growth inhibitory effect or heme oxygenase-1 (HMOX1) gene transcriptional induction activity in T-47D breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 1423715-30-3
Molecular Weight 381.83
Formula C₁₆H₁₆ClN₃O₄S
SMILES

C(N/N=C(\C)/C1=C(O)C=CC(Cl)=C1)(=O)C2=CC(S(NC)(=O)=O)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Smith J, et al. Inhibitors of Hepatitis C Virus NS5B Polymerase. US20140163017 A1. United States Patent and Trademark Office. 2014-06-12.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote