ME1 - malic enzyme 1 Gene

Also Known as MES; HUMNDME

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4199

About ME1

Cytogenetic location: 6q14.2 Genomic coordinates (GRCh38): 6:83,210,402-83,431,051 (from NCBI)

This gene has 1 transcript (splice variant), 220 orthologues and 2 paralogues. Broad expression in fat (RPKM 29.4), adrenal (RPKM 23.1) and 21 other tissues.

Summary

This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid Hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]

ME1 Products (1)

mRNA Protein Name
NM_002395.6 NP_002386.1 NADP-dependent malic enzyme

ME1 Protein Structure

malic

malic: Malic enzyme, N-terminal domain (79 - 260)

Malic_M

Malic_M: Malic enzyme, NAD binding domain (270 - 522)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 572 a.a.
Protein Preferred Names Protein Names

NADP-dependent malic enzyme

  • Malic enzyme, cytoplasmic

ME1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ME1 P48163 PC Homo sapiens P11498
Anti Bait CoIP
34547241
Intra
ME1 P48163 ME1 Homo sapiens P48163
Y2H Array
32296183
Intra
ME1 P48163 MDH1 Homo sapiens P40925
Anti Bait CoIP
34547241
Intra
ME1 P48163 ME1 Homo sapiens P48163
Y2H Prey Pooling
32296183
Intra
ME1 P48163 PC Homo sapiens P11498
BN-PAGE
34547241
Intra
ME1 P48163 PC Homo sapiens P11498
Confocal
34547241
Intra
ME1 P48163 PC Homo sapiens P11498
GMS
34547241
Intra
ME1 P48163 MDH1 Homo sapiens P40925
Anti Tag CoIP
34547241
Intra
ME1 P48163 ME1 Homo sapiens P48163
Validated Y2H
32296183
Intra
ME1 P48163 PC Homo sapiens P11498
Anti Tag CoIP
34547241
Intra
ME1 P48163 ME1 Homo sapiens P48163
GMS
34547241
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99595 Sirtratumab vedotin 97.38% Phase 1
HY-172661 Kylo-0603 / Phase 1

Pre-clinical Phase

Bioactive Molecules (29)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15227 EPZ004777 99.74% Unkown
HY-124861 Malic enzyme inhibitor ME1 Inhibitor 99.69% Unkown
HY-403538 iZMYND8-34 Inhibitor 98.89% Unkown
HY-150621 AS1134900 Activator 98.87% Unkown
HY-15227A EPZ004777 hydrochloride 98.92% Unkown
HY-149677 ZK53 99.19% Unkown
HY-149091 KDM5B-IN-4 Inhibitor 99.68% Unkown
HY-128912 Arborinine Inhibitor 99.87% Unkown
HY-149213 LSD1/TLK1-IN-1 99.20% Unkown
HY-P2254 H3K27(Me3) (15-34) 96.97% Unkown
HY-P2255 H3K4(Me) (1-20) 99.87% Unkown
HY-RS08270 ME1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-115619 EPZ004777 formate / Unkown
HY-124961 LSD1-IN-2 Inhibitor / Unkown
HY-158436 Antitumor agent-155 / Unkown
HY-164144 EPZ033294 Inhibitor 98.41% Unkown
HY-168086 LSD1-IN-35 Inhibitor / Unkown
HY-174450 KMT9-IN-1 Inhibitor / Unkown
HY-176283 Tubulin/LSD1-IN-1 / Unkown
HY-181781 LSD1-IN-48 / Unkown
HY-181849 MS2928 Inhibitor / Unkown
HY-182054 Topoisomerase ll/ME-1-IN-1 / Unkown
HY-P10819 S9-CMC1 TFA / Unkown
HY-P2252 H3K27(Me) (15-34) / Unkown
HY-P2253 H3K27(Me2) (15-34) / Unkown
HY-RS10137 PCDHB16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17185 Me1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21063 Tcf12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23636 Me1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991080 Anti-SLC44A4 Antibody ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ME1 VGNC VGNC:68225
Rattus norvegicus ME1 RGD RGD:3074
Canis familiaris ME1 VGNC VGNC:43109
Mus musculus ME1 MGD MGI:97043
Macaca mulatta ME1 VGNC VGNC:74694
Bos taurus ME1 VGNC VGNC:31339
Others ME1 NCBI