2. Gene
  3. ME1 - malic enzyme 1 Gene

ME1 - malic enzyme 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MES; HUMNDME

Gene ID: 4199 | Gene type: protein coding

About ME1

Cytogenetic location: 6q14.2 Genomic coordinates (GRCh38): 6:83,210,402-83,431,051 (from NCBI)

This gene has 1 transcript (splice variant), 220 orthologues and 2 paralogues. Broad expression in fat (RPKM 29.4), adrenal (RPKM 23.1) and 21 other tissues.

Summary

This gene encodes a cytosolic, NADP-dependent Enzyme that generates NADPH for fatty acid biosynthesis. The activity of this Enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid Hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]

ME1 Products(1)

mRNA Protein Name
NM_002395.6 NP_002386.1 NADP-dependent malic enzyme

ME1 Protein Structure

malic

malic: Malic enzyme, N-terminal domain (79 - 260)

Malic_M

Malic_M: Malic enzyme, NAD binding domain (270 - 522)

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  • 572 a.a.
Protein Preferred Names Protein Names

NADP-dependent malic enzyme

Malic enzyme, cytoplasmic

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-124861 Malic enzyme inhibitor ME1 Inhibitor 99.53% Unkown
HY-150621 AS1134900 98.44% Unkown
HY-149677 ZK53 98.94% Unkown
HY-128912 Arborinine Inhibitor / Unkown
HY-149091 KDM5B-IN-4 / Unkown
HY-D0858S MES-13d / Unkown
HY-RS08270 ME1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ME1 VGNC VGNC:68225
Rattus norvegicus ME1 RGD RGD:3074
Canis familiaris ME1 VGNC VGNC:43109
Mus musculus ME1 MGD MGI:97043
Macaca mulatta ME1 VGNC VGNC:74694
Bos taurus ME1 VGNC VGNC:31339
Others ME1 NCBI