Map1b - microtubule-associated protein 1B Gene

Also Known as LC1; MAP5; Mtap5; Mtap-5; Mtap1b; A230055D22

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17755

Summary

Predicted to enable actin binding activity; microtubule binding activity; and phospholipid binding activity. Acts upstream of or within several processes, including establishment of monopolar cell polarity; mitochondrion transport along microtubule; and neuron projection development. Located in several cellular components, including neuronal cell body; photoreceptor outer segment; and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; intestine smooth muscle circular layer; nose; and trigeminal nerve. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human MAP1B (microtubule associated protein 1B). [provided by Alliance of Genome Resources, Apr 2022]

Map1b Products (1)

mRNA	Protein	Name
NM_008634.2	NP_032660.2	microtubule-associated protein 1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17308336	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within axon extension	IMP IMP: Inferred from mutant phenotype	16536727	MGI
acts upstream of or within axonogenesis	IGI IGI: Inferred from genetic interaction	11891784	MGI
acts upstream of or within dendrite development	IMP IMP: Inferred from mutant phenotype	11581286	MGI
acts upstream of or within establishment of monopolar cell polarity	IMP IMP: Inferred from mutant phenotype	11029282	MGI
acts upstream of intracellular transport	IMP IMP: Inferred from mutant phenotype	16536727	MGI
acts upstream of or within microtubule bundle formation	IMP IMP: Inferred from mutant phenotype	11581286	MGI
acts upstream of or within mitochondrion transport along microtubule	IMP IMP: Inferred from mutant phenotype	16536727	MGI
acts upstream of or within negative regulation of intracellular transport	IMP IMP: Inferred from mutant phenotype	16536727	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	21984824	MGI
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	21984824	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	16885219	MGI
located in dendrite	IDA IDA: Inferred from direct assay	25788676	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21984824	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21984824	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	25788676	MGI
located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	24664738	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	21984824	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
microtubule-associated protein 1B	MAP-1B MAP1(X) MAP1.2 Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) microtubule-associated protein 5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS18395	Map1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08027	MAP1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24876	Map1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map1b	NCBI	NCBI:4131