Mttp - microsomal triglyceride transfer protein Gene

Also Known as MTP; 1810043K16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17777

About Mttp

Chromosome 3: 137,795,615-137,850,729 reverse strand.GRCm39:CM000996.3

This gene has 3 transcripts (splice variants), 210 orthologues and is associated with 20 phenotypes. Biased expression in large intestine adult (RPKM 62.5), duodenum adult (RPKM 33.4) and 6 other tissues.

Summary

Enables Cholesterol transfer activity; phosphatidylethanolamine transfer activity; and triglyceride transfer activity. Acts upstream of or within several processes, including Cholesterol homeostasis; lipoprotein transport; and low-density lipoprotein particle remodeling. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in gut; liver; placenta; septum transversum hepatic component; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including abdominal obesity-metabolic syndrome 1; abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein). [provided by Alliance of Genome Resources, Apr 2022]

Mttp Products (4)

mRNA Protein Name
NM_008642.3 NP_032668.2 microsomal triglyceride transfer protein large subunit isoform 2 precursor
NM_001163457.2 NP_001156929.1 microsomal triglyceride transfer protein large subunit isoform 1 precursor
NM_001355051.1 NP_001341980.1 microsomal triglyceride transfer protein large subunit isoform 2 precursor
NM_001355052.1 NP_001341981.1 microsomal triglyceride transfer protein large subunit isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cholesterol transfer activity IDA
IDA: Inferred from direct assay
15897609 MGI
enables lipid transporter activity IDA
IDA: Inferred from direct assay
12072432 MGI
enables phosphatidylethanolamine transfer activity IDA
IDA: Inferred from direct assay
15897609 MGI
enables phospholipid transfer activity IDA
IDA: Inferred from direct assay
33168624 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
33168624 MGI
enables triglyceride transfer activity IDA
IDA: Inferred from direct assay
15897609 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
10713055 MGI
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
24353284 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
10713055 MGI
acts upstream of or within lipid metabolic process IDA
IDA: Inferred from direct assay
12072432 MGI
acts upstream of or within lipoprotein metabolic process IMP
IMP: Inferred from mutant phenotype
10713055 MGI
acts upstream of or within lipoprotein transport IMP
IMP: Inferred from mutant phenotype
10713055 MGI
acts upstream of or within low-density lipoprotein particle remodeling IDA
IDA: Inferred from direct assay
27471003 MGI
acts upstream of or within protein lipidation IDA
IDA: Inferred from direct assay
12072432 MGI
acts upstream of or within triglyceride metabolic process IDA
IDA: Inferred from direct assay
12072432 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
33168624 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mttp Protein Structure

Vitellogenin_N

Vitellogenin_N: cl44413 (27 - 578)

MTP_lip_bd

MTP_lip_bd: pfam19444 (590 - 884)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 894 a.a.
Protein Preferred Names Protein Names

microsomal triglyceride transfer protein large subunit

  • microsomal triglyceride transfer protein B

  • microsomal triglyceride transfer protein, large subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50670 DGAT-1 inhibitor 2 95.33% Unkown
HY-RS08822 MTTP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08823 Mttp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08824 Mttp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mttp NCBI NCBI:4547