Nfe2 - nuclear factor, erythroid derived 2 Gene

Also Known as p45; NF-E2; p45NFE2; p45nf-e2; NF-E2/P45

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18022

Summary

Predicted to enable several functions, including WW domain binding activity; identical protein binding activity; and protein N-terminus binding activity. Predicted to contribute to cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of bone mineralization; and negative regulation of syncytium formation by plasma membrane fusion. Located in nucleus. Is expressed in several structures, including dorsal aorta; eye; genitourinary system; limb; and yolk sac. Orthologous to human NFE2 (nuclear factor, erythroid 2). [provided by Alliance of Genome Resources, Apr 2022]

Nfe2 Products (7)

mRNA Protein Name
NM_001302338.2 NP_001289267.1 transcription factor NF-E2 45 kDa subunit
NM_001302339.2 NP_001289268.1 transcription factor NF-E2 45 kDa subunit
NM_001302340.2 NP_001289269.1 transcription factor NF-E2 45 kDa subunit
NM_001302341.2 NP_001289270.1 transcription factor NF-E2 45 kDa subunit
NM_001302343.2 NP_001289272.1 transcription factor NF-E2 45 kDa subunit
NM_001400376.1 NP_001387305.1 transcription factor NF-E2 45 kDa subunit
NM_008685.4 NP_032711.2 transcription factor NF-E2 45 kDa subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19822740 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of bone mineralization IMP
IMP: Inferred from mutant phenotype
15005853 MGI
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
11113182 MGI
acts upstream of or within cell-cell signaling IMP
IMP: Inferred from mutant phenotype
15005853 MGI
acts upstream of or within gene expression IDA
IDA: Inferred from direct assay
28411267 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
28411267 MGI
acts upstream of or within labyrinthine layer blood vessel development IMP
IMP: Inferred from mutant phenotype
21558372 MGI
acts upstream of or within negative regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
15005853 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11113182 MGI
acts upstream of or within negative regulation of syncytium formation by plasma membrane fusion IGI
IGI: Inferred from genetic interaction
21558372 MGI
acts upstream of or within negative regulation of syncytium formation by plasma membrane fusion IMP
IMP: Inferred from mutant phenotype
21558372 MGI
acts upstream of or within positive regulation of peptidyl-lysine acetylation IMP
IMP: Inferred from mutant phenotype
21558372 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
11113182 MGI
acts upstream of syncytium formation by plasma membrane fusion IGI
IGI: Inferred from genetic interaction
21558372 MGI
acts upstream of syncytium formation by plasma membrane fusion IMP
IMP: Inferred from mutant phenotype
21558372 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
7995373 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor NF-E2 45 kDa subunit

  • leucine zipper protein NF-E2

  • nuclear factor, erythroid derived 2, 45 kDa

  • nuclear factor, erythroid-derived 2 45 kDa subunit

Nfe2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nfe2 Q07279 Ciita Mus musculus P79621
Pull Down
20211142
Intra
Nfe2 Q07279 Rps27a Mus musculus P62991
Anti Bait CoIP
19966288
Intra
Nfe2 Q07279 Ehmt2 Mus musculus Q9Z148-1
Anti Bait CoIP
19822740
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12213 CDDO-EA Activator 99.78% Unkown
HY-RS09245 NFE2L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09246 Nfe2l2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145390 Nrf2 activator-1 Activator 98.66% Unkown
HY-145390A (R,R)-Nrf2 activator-1 Activator 96.88% Unkown
HY-N6802 Tigloylgomisin H Inducer 98.37% Unkown
HY-RS19795 Nfe2l3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-177944 DC-PGKI / Unkown
HY-178997 NFE2L1 activator-1 98.93% Unkown
HY-RS09243 NFE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09244 NFE2L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09247 Nfe2l2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09248 NFE2L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-125995 NFE2L2 activator 3 Activator / Unkown
HY-RS18144 Nfe2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20770 Mafk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21165 Nfe2l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24619 Nfe2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26291 Nfe2l3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27681 Nfe2l1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfe2 NCBI NCBI:4778