NFE2 - nuclear factor, erythroid 2 Gene

Also Known as p45; NF-E2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4778

About NFE2

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,292,111-54,301,015 (from NCBI)

This gene has 5 transcripts (splice variants), 188 orthologues and 3 paralogues. Biased expression in bone marrow (RPKM 31.8), spleen (RPKM 3.5) and 3 other tissues.

Summary

Enables several functions, including WW domain binding activity; identical protein binding activity; and protein N-terminus binding activity. Contributes to cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of bone mineralization; and negative regulation of syncytium formation by plasma membrane fusion. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Apr 2022]

NFE2 Products (6)

mRNA	Protein	Name
NM_001136023.3	NP_001129495.1	transcription factor NF-E2 45 kDa subunit isoform 1
NM_001261461.2	NP_001248390.1	transcription factor NF-E2 45 kDa subunit isoform 1
NM_001400365.1	NP_001387294.1	transcription factor NF-E2 45 kDa subunit isoform 1
NM_001400372.1	NP_001387301.1	transcription factor NF-E2 45 kDa subunit isoform 2
NM_001400373.1	NP_001387302.1	transcription factor NF-E2 45 kDa subunit isoform 2
NM_006163.3	NP_006154.1	transcription factor NF-E2 45 kDa subunit isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12609092	GOA
enables WW domain binding	IDA IDA: Inferred from direct assay	9305852	GOA
enables WW domain binding	IPI IPI: Inferred from physical interaction	9305852	GOA
contributes to cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16263792	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20102225	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11863372	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	12609092	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFE2 Protein Structure

bZIP_Maf

0
100
200
300
373 a.a.

Protein Preferred Names	Protein Names
transcription factor NF-E2 45 kDa subunit	leucine zipper protein NF-E2

NFE2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NFE2	Q16621	NFE2L3	Homo sapiens	Q9Y4A8	Peptide Array	20102225
Intra	NFE2	Q16621	NFE2L3	Homo sapiens	Q9Y4A8	FRET	23661758
Intra	NFE2	Q16621	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	NFE2	Q16621	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	NFE2	Q16621	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	NFE2	Q16621	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	NFE2	Q16621	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	NFE2	Q16621	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	NFE2	Q16621	BTRC	Homo sapiens	Q9Y297	Validated Y2H	25416956
Intra	NFE2	Q16621	BTRC	Homo sapiens	Q9Y297	Y2H Prey Pooling	25416956
Intra	NFE2	Q16621	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	NFE2	Q16621	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	NFE2	Q16621	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	NFE2	Q16621	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	NFE2	Q16621	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	NFE2	Q16621	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	NFE2	Q16621	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	NFE2	Q16621	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	NFE2	Q16621	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	NFE2	Q16621	NFE2	Homo sapiens	Q16621	Peptide Array	20102225
Intra	NFE2	Q16621	NFE2	Homo sapiens	Q16621	FRET	23661758
Cross	NFE2	Q16621	MDV005	Gallid herpesvirus 2	Q9DGW5	Peptide Array	20102225

Cross: Cross-species interaction Intra: Intraspecies interaction

NFE2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81464	NFE2 Antibody (YA1209)	IHC-P	Human
HY-P81464A	NFE2 Antibody (YA1209)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Erythroleukemia
Polycythemia	Erythrocythemia Polycythemia Vera Polycythaemia Due To High Altitude
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Acute Erythroid Leukemia	Acute Erythroleukemia Di Guglielmo'S Syndrome Aml M6 Acute Myeloid Leukemia Fab-M6 Acute Myeloid Leukemia M6 Erythroleukemia Aml-M6 Acute Erythroleukemia M6a Subtype Acute Erythroleukemia M6b Subtype Di Guglielmo Syndrome Acute Myeloid Leukemia, M6 Type Acute Erythroblastic Leukemia Acute Erythroleukemia - M6a Subtype Acute Erythroleukemia - M6b Subtype Acute Erythraemia And Erythroleukaemia Acute Erythroid Leukaemia Without Mention Of Remission Erythraemia Erythraemic Myelosis Erythroleukaemia Acute Erythraemic Myelosis Acute Erythraemia
Hemoglobin H Disease	HBH Hemoglobin H Disease, Nondeletional Hemoglobin H Disease, Deletional Alpha-Thalassemia Intermedia Haemoglobin H Disease Alpha-Thalassemia, Hemoglobin H Type Hemoglobin H Disease, Deletional And Nondeletional Alpha Thalassemia, Haemoglobin H Type Alpha Thalassemia, Hemoglobin H Type Haemoglobin H Disease, Deletional Hbh Disease Alpha-Thalassemia Hemoglobin H Type Hemoglobin H Disease Deletional Hemoglobin H Disease Non-Deletional Alpha-Thalassemia Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia Alpha Thalassaemia Intermedia
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Deficiency Anemia	Anemia Deficiency Anemias Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12213	CDDO-EA	Activator	99.78%	Unkown
HY-RS09245	NFE2L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09246	Nfe2l2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-145390	Nrf2 activator-1	Activator	98.66%	Unkown
HY-145390A	(R,R)-Nrf2 activator-1	Activator	96.88%	Unkown
HY-N6802	Tigloylgomisin H	Inducer	98.37%	Unkown
HY-RS19795	Nfe2l3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-177944	DC-PGKI		/	Unkown
HY-178997	NFE2L1 activator-1		98.93%	Unkown
HY-RS09243	NFE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09244	NFE2L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09247	Nfe2l2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09248	NFE2L3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-125995	NFE2L2 activator 3	Activator	/	Unkown
HY-RS18144	Nfe2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20770	Mafk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21165	Nfe2l1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24619	Nfe2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26291	Nfe2l3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27681	Nfe2l1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NFE2	VGNC	VGNC:68473
Macaca mulatta	NFE2	VGNC	VGNC:75330
Canis familiaris	NFE2	VGNC	VGNC:43771
Mus musculus	NFE2	MGD	MGI:97308
Bos taurus	NFE2	VGNC	VGNC:32034
Rattus norvegicus	NFE2	RGD	RGD:1306888
Others	NFE2	NCBI