Ccn3 - cellular communication network factor 3 Gene

Also Known as Nov; C130088N23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18133

Summary

Predicted to enable Notch binding activity; heparin binding activity; and Integrin binding activity. Involved in several processes, including bone regeneration; negative regulation of cell communication; and type B pancreatic cell proliferation. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human CCN3 (cellular communication network factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Ccn3 Products (1)

mRNA Protein Name
NM_010930.5 NP_035060.1 CCN family member 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone activity IDA
IDA: Inferred from direct assay
38987585 MGI
Biological Process GO Annotation Evidence References Source
involved in bone regeneration IMP
IMP: Inferred from mutant phenotype
23653360 MGI
acts upstream of positive effect negative regulation of SMAD protein signal transduction IMP
IMP: Inferred from mutant phenotype
23653360 MGI
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
24722330 MGI
involved in negative regulation of insulin secretion IDA
IDA: Inferred from direct assay
23705021 MGI
involved in positive regulation of ossification IDA
IDA: Inferred from direct assay
38987585 MGI
involved in smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
20139355 MGI
involved in type B pancreatic cell proliferation IDA
IDA: Inferred from direct assay
23705021 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
38987585 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CCN family member 3

  • nephroblastoma overexpressed

  • nephroblastoma-overexpressed gene protein homolog

  • novH

  • protein NOV homolog

Recombinant Ccn3 Proteins

Cat. No. Product Name Accession Purity
HY-P71149 NOV/CCN3 Protein, Mouse (HEK293, His) Q64299 (S26-I354) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02112 CCN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17879 Ccn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24348 Ccn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccn3 NCBI NCBI:4856