Nrg3 - neuregulin 3 Gene

Also Known as ska

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18183

Summary

Enables chemorepellent activity. Acts upstream of or within several processes, including intracellular signal transduction; mammary placode formation; and regulation of cell migration. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space and glutamatergic synapse. Is expressed in several structures, including epidermis; mammary gland primordium; nervous system; testis; and trunk mesenchyme. Used to study schizophrenia. Orthologous to human NRG3 (neuregulin 3). [provided by Alliance of Genome Resources, Apr 2022]

Nrg3 Products (3)

mRNA	Protein	Name
NM_001190187.1	NP_001177116.1	pro-neuregulin-3, membrane-bound isoform isoform 2
NM_001190188.1	NP_001177117.1	pro-neuregulin-3, membrane-bound isoform isoform 3
NM_008734.3	NP_032760.1	pro-neuregulin-3, membrane-bound isoform isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chemorepellent activity	IDA IDA: Inferred from direct assay	22376909	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9275162	MGI
enables receptor ligand activity	IPI IPI: Inferred from physical interaction	9275162	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in ERBB4 signaling pathway	IPI IPI: Inferred from physical interaction	9275162	MGI
involved in ERBB4-ERBB4 signaling pathway	IPI IPI: Inferred from physical interaction	9275162	MGI
acts upstream of or within chemorepulsion involved in interneuron migration from the subpallium to the cortex	IMP IMP: Inferred from mutant phenotype	22376909	MGI
acts upstream of or within intracellular signal transduction	IDA IDA: Inferred from direct assay	9275162	MGI
acts upstream of or within mammary gland development	IDA IDA: Inferred from direct assay	16140987	MGI
acts upstream of or within mammary gland development	IMP IMP: Inferred from mutant phenotype	16140987	MGI
acts upstream of or within mammary placode formation	IMP IMP: Inferred from mutant phenotype	10723730	MGI
acts upstream of or within negative regulation of neuron migration	IDA IDA: Inferred from direct assay	22376909	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	10723730	MGI
involved in synapse assembly	IDA IDA: Inferred from direct assay	30049711	MGI
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	30049711	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	30049711	MGI
is active in extracellular space	IPI IPI: Inferred from physical interaction	9275162	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	30049711	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	30049711	MGI
is active in synapse	IDA IDA: Inferred from direct assay	33320083	MGI
is active in synapse	IMP IMP: Inferred from mutant phenotype	33320083	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
pro-neuregulin-3, membrane-bound isoform	pro-NRG3 scaramanga

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09568	NRG3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174565	Human NRG3 mRNA		/	Unkown
HY-RS17691	Nrg3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24153	Nrg3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nrg3	NCBI	NCBI:10718