P2rx1 - purinergic receptor P2X, ligand-gated ion channel, 1 Gene

Also Known as P2x; RP-2; Pdcd3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18436

About P2rx1

Chromosome 11: 72,889,929-72,906,026 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 199 orthologues, 6 paralogues and is associated with 5 phenotypes. Biased expression in bladder adult (RPKM 22.3) and thymus adult (RPKM 21.4).

Summary

Enables cation channel activity and purinergic nucleotide receptor activity. Acts upstream of or within several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of ion transport; and serotonin secretion by platelet. Located in external side of plasma membrane and postsynaptic membrane. Is expressed in several structures, including bladder; foregut-midgut junction; heart; liver lobe; and midgut. Orthologous to human P2RX1 (purinergic receptor P2X 1). [provided by Alliance of Genome Resources, Apr 2022]

P2rx1 Products (1)

mRNA Protein Name
NM_008771.3 NP_032797.3 P2X purinoceptor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables monoatomic cation channel activity IMP
IMP: Inferred from mutant phenotype
10638758 MGI
enables purinergic nucleotide receptor activity IMP
IMP: Inferred from mutant phenotype
10638758 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
16325464 MGI
acts upstream of or within ceramide biosynthetic process IDA
IDA: Inferred from direct assay
16325464 MGI
acts upstream of establishment of localization in cell IGI
IGI: Inferred from genetic interaction
15914557 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
15914557 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
10638758 MGI
acts upstream of or within insemination IMP
IMP: Inferred from mutant phenotype
10638758 MGI
acts upstream of monoatomic ion transport IGI
IGI: Inferred from genetic interaction
15914557 MGI
acts upstream of monoatomic ion transport IMP
IMP: Inferred from mutant phenotype
15914557 MGI
acts upstream of or within monoatomic ion transport IMP
IMP: Inferred from mutant phenotype
10638758 MGI
acts upstream of or within platelet activation IMP
IMP: Inferred from mutant phenotype
12913094 MGI
acts upstream of or within positive regulation of monoatomic ion transport IGI
IGI: Inferred from genetic interaction
15914557 MGI
acts upstream of or within positive regulation of monoatomic ion transport IMP
IMP: Inferred from mutant phenotype
15914557 MGI
acts upstream of or within regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
16920810 MGI
acts upstream of or within regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
10638758 MGI
acts upstream of or within regulation of vascular associated smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
16920810 MGI
acts upstream of or within regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
14679185 MGI
acts upstream of or within response to ATP IMP
IMP: Inferred from mutant phenotype
14679185 MGI
acts upstream of or within serotonin secretion by platelet IMP
IMP: Inferred from mutant phenotype
12913094 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
11570704 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
11668586 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx1 Protein Structure

P2X

P2X: TIGR00863 (0 - 367)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
Protein Preferred Names Protein Names

P2X purinoceptor 1

  • ATP receptor

  • P2X1 receptor

  • programmed cell death 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09897 P2RX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09898 P2rx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09899 P2rx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2rx1 NCBI NCBI:5023