P2rx4 - purinergic receptor P2X, ligand-gated ion channel 4 Gene

Also Known as P2X4; D5Ertd444e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18438

About P2rx4

Chromosome 5: 122,845,607-122,867,801 forward strand.GRCm39:CM000998.3

This gene has 9 transcripts (splice variants), 211 orthologues, 6 paralogues and is associated with 13 phenotypes. Ubiquitous expression in colon adult (RPKM 57.8), lung adult (RPKM 28.) and 23 other tissues.

Summary

Enables extracellularly ATP-gated cation channel activity. Acts upstream of or within several processes, including excitatory postsynaptic potential; nitric oxide biosynthetic process; and vasodilation. Located in apical part of cell. Is expressed in several structures, including cardiovascular system; gut; immune system; nervous system; and viscerocranium. Orthologous to human P2RX4 (purinergic receptor P2X 4). [provided by Alliance of Genome Resources, Apr 2022]

P2rx4 Products (6)

mRNA Protein Name
NM_001310720.1 NP_001297649.1 P2X purinoceptor 4 isoform 3
NM_011026.3 NP_035156.2 P2X purinoceptor 4 isoform 1
NM_001310718.1 NP_001297647.1 P2X purinoceptor 4 isoform 2
NM_001310718.1 NP_001297647.1 P2X purinoceptor 4 isoform 2
NM_001310720.1 NP_001297649.1 P2X purinoceptor 4 isoform 3
NM_011026.3 NP_035156.2 P2X purinoceptor 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables extracellularly ATP-gated monoatomic cation channel activity IMP
IMP: Inferred from mutant phenotype
15081800 MGI
enables ligand-gated monoatomic cation channel activity IDA
IDA: Inferred from direct assay
27477609 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
16327800 MGI
acts upstream of or within excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
16943557 MGI
acts upstream of or within nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
16327800 MGI
acts upstream of or within nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
16327800 MGI
acts upstream of or within vasodilation IMP
IMP: Inferred from mutant phenotype
16327800 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
17560948 MGI
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
27477609 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx4 Protein Structure

P2X_receptor

P2X_receptor: pfam00864 (12 - 360)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

P2X purinoceptor 4

  • ionotropic purinergic receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09906 P2RX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09907 P2rx4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09908 P2rx4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2rx4 NCBI NCBI:5025