2. Gene
  3. Kat2b - K(lysine) acetyltransferase 2B Gene

Kat2b - K(lysine) acetyltransferase 2B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pcaf; p/CAF; A930006P13Rik

Gene ID: 18519 | Gene type: protein coding

About Kat2b

Chromosome 17: 53,873,889-53,979,748 forward strand.GRCm39:CM001010.3

This gene has 7 transcripts (splice variants), 225 orthologues, 11 paralogues and is associated with 11 phenotypes. Ubiquitous expression in adrenal adult (RPKM 12.8), bladder adult (RPKM 11.9) and 28 other tissues.

Summary

Enables several functions, including N-acetyltransferase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and transcription coactivator activity. Involved in internal peptidyl-lysine acetylation and negative regulation of cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within histone H3-K9 acetylation; positive regulation of gluconeogenesis; and positive regulation of transcription by RNA polymerase II. Located in several cellular components, including actomyosin; kinetochore; and sarcomere. Part of ATAC complex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; liver; and lung. Orthologous to human KAT2B (lysine acetyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]

Kat2b Products(2)

mRNA Protein Name
NM_020005.4 NP_064389.2 histone acetyltransferase KAT2B isoform 1
NM_001190846.1 NP_001177775.1 histone acetyltransferase KAT2B isoform 2

Kat2b Protein Structure

PCAF_N

PCAF_N: pfam06466 (55 - 306)

COG5076

COG5076: cl34891 (467 - 806)

Bromo_gcn5_like

Bromo_gcn5_like: cd05509 (707 - 806)

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  • 813 a.a.
Protein Preferred Names Protein Names

histone acetyltransferase KAT2B

histone acetylase PCAF

histone acetyltransferase PCAF

lysine acetyltransferase 2B

p300/CBP-associated factor

spermidine acetyltransferase KAT2B

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W015239 KAT8-IN-1 99.40% Unkown
HY-RS07077 KAT2B Human Pre-designed siRNA Set A / Unkown
HY-RS07078 Kat2b Mouse Pre-designed siRNA Set A / Unkown
HY-RS07079 KAT2B Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kat2b NCBI NCBI:8850