Pde4a - phosphodiesterase 4A, cAMP specific Gene

Also Known as Dpde2; D9Ertd60e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18577

About Pde4a

Chromosome 9: 21,077,010-21,124,544 forward strand.GRCm39:CM001002.3

This gene has 5 transcripts (splice variants), 261 orthologues and 20 paralogues. Broad expression in testis adult (RPKM 2.4), frontal lobe adult (RPKM 16.) and 22 other tissues.

Summary

Enables 3',5'-cyclic-AMP phosphodiesterase activity. Acts upstream of or within cellular response to xenobiotic stimulus; regulation of signal transduction; and sensory perception of smell. Located in cytosol and membrane. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Orthologous to human PDE4A (phosphodiesterase 4A). [provided by Alliance of Genome Resources, Apr 2022]

Pde4a Products (11)

mRNA Protein Name
NM_001409297.1 NP_001396226.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 10
NM_001409295.1 NP_001396224.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 9
NM_001409293.1 NP_001396222.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 8
NM_019798.6 NP_062772.3 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 1
NM_001409294.1 NP_001396223.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 8
NM_001409292.1 NP_001396221.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 7
NM_001409296.1 NP_001396225.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 10
NM_001310750.2 NP_001297679.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 6
NM_001409289.1 NP_001396218.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
NM_001409291.1 NP_001396220.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4
NM_183408.4 NP_899668.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
11267656 MGI
Biological Process GO Annotation Evidence References Source
involved in cAMP catabolic process IDA
IDA: Inferred from direct assay
11267656 MGI
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
11267656 MGI
acts upstream of or within regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18923023 MGI
acts upstream of or within regulation of cAMP/PKA signal transduction IMP
IMP: Inferred from mutant phenotype
18923023 MGI
acts upstream of or within sensory perception of smell IGI
IGI: Inferred from genetic interaction
19305400 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19305400 MGI
located in cytosol IDA
IDA: Inferred from direct assay
23008439 MGI
located in membrane IDA
IDA: Inferred from direct assay
23008439 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pde4a Protein Structure

PDE4_UCR

PDE4_UCR: pfam18100 (172 - 287)

PDEase_I

PDEase_I: pfam00233 (417 - 657)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 844 a.a.
Protein Preferred Names Protein Names

cAMP-specific 3',5'-cyclic phosphodiesterase 4A

  • cAMP-specific phosphodiesterase PDE4A

  • cyclic AMP specific phosphodiesterase PDE4A5A

  • dunce

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1639 Enoximone Inhibitor 99.91% Unkown

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-108047 MK-0873 Inhibitor 95.0% Phase 2
HY-106003 GSK356278 Inhibitor 99.82% Phase 1
HY-131707 LEO 39652 Inhibitor 99.40% Phase 1
HY-201403 LY2775240 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119190 PF-06445974 Inhibitor 98.59% Unkown
HY-16900A (R)-(-)-Rolipram Inhibitor 99.91% Unkown
HY-103050 ML-030 Inhibitor 99.28% Unkown
HY-131340 LASSBio-1632 Inhibitor / Unkown
HY-114052 NVP-ABE171 Inhibitor / Unkown
HY-122167 L-869298 Inhibitor / Unkown
HY-134937 BC8-15 Inhibitor / Unkown
HY-179504 PDE4B-IN-6 Inhibitor / Unkown
HY-RS10220 PDE4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10221 Pde4a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10222 Pde4a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde4a NCBI NCBI:5141