Pde9a - phosphodiesterase 9A Gene

Also Known as PDE9A1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18585

About Pde9a

Chromosome 17: 31,605,184-31,695,284 forward strand.GRCm39:CM001010.3

This gene has 28 transcripts (splice variants), 192 orthologues, 20 paralogues and is associated with 1 phenotype. Broad expression in colon adult (RPKM 62.7), large intestine adult (RPKM 61.1) and 19 other tissues.

Summary

Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP catabolic process and positive regulation of cardiac muscle hypertrophy. Predicted to be located in several cellular components, including nucleoplasm; perikaryon; and sarcolemma. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human PDE9A (phosphodiesterase 9A). [provided by Alliance of Genome Resources, Apr 2022]

Pde9a Products (7)

mRNA Protein Name
NM_001410690.1 NP_001397619.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4
NM_001410691.1 NP_001397620.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4
NM_001163748.2 NP_001157220.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 1
NM_008804.5 NP_032830.3 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 1
NM_001410687.1 NP_001397616.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 2
NM_001410688.1 NP_001397617.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 3
NM_001410689.1 NP_001397618.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
9624145 MGI
Biological Process GO Annotation Evidence References Source
involved in cGMP catabolic process IDA
IDA: Inferred from direct assay
9624145 MGI
involved in cGMP catabolic process IMP
IMP: Inferred from mutant phenotype
25799991 MGI
involved in positive regulation of cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
25799991 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pde9a Protein Structure

PDEase_I

PDEase_I: pfam00233 (249 - 477)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 534 a.a.
Protein Preferred Names Protein Names

high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15441 Edelinontrine Inhibitor 99.85% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-104028 BAY 73-6691 Inhibitor 99.38% Unkown
HY-12788 PF-04449613 Inhibitor 99.83% Unkown
HY-126137 PDE9-IN-1 Inhibitor 99.70% Unkown
HY-152106 BAY-7081 Inhibitor 99.03% Unkown
HY-104028B (S)-BAY 73-6691 Control 99.71% Unkown
HY-12788A (S)-PF-04449613 Inhibitor 99.85% Unkown
HY-152106A (+)-BAY-7081 Inhibitor 99.21% Unkown
HY-152106B (±)-BAY-7081 Inhibitor 99.06% Unkown
HY-RS10246 PDE9A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10247 Pde9a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10248 Pde9a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde9a NCBI NCBI:5152