Pfkfb2 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Gene

Also Known as 4930568D07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18640

Summary

Enables fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in several processes, including fructose 2,6-bisphosphate metabolic process; monocarboxylic acid metabolic process; and positive regulation of Glucokinase activity. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]

Pfkfb2 Products (4)

mRNA Protein Name
NM_001162415.1 NP_001155887.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 2
NM_001162416.1 NP_001155888.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 3
NM_001368843.1 NP_001355772.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 4
NM_008825.4 NP_032851.2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables 6-phosphofructo-2-kinase activity IMP
IMP: Inferred from mutant phenotype
15331593 MGI
enables fructose-2,6-bisphosphate 2-phosphatase activity IDA
IDA: Inferred from direct assay
18039179 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

  • 6PF-2-K/Fru-2,6-P2ase 2

  • 6PF-2-K/Fru-2,6-P2ase heart-type isozyme

  • PFK-2/FBPase-2 gene B

  • PFK/FBPase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101972 AZ-PFKFB3-67 Inhibitor 97.03% Unkown
HY-101971 AZ PFKFB3 26 Inhibitor 99.23% Unkown
HY-101972A AZ-PFKFB3-67 quarterhydrate Inhibitor 99.0% Unkown
HY-184148 PFKFB3-IN-3 Inhibitor / Unkown
HY-RS10362 PFKFB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20188 Pfkfb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26692 Pfkfb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pfkfb2 NCBI NCBI:5208