Abcb4 - ATP-binding cassette, sub-family B (MDR/TAP), member 4 Gene

Also Known as Mdr2; Pgy2; Pgy-2; mdr-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18670

Summary

Predicted to enable ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in bile acid secretion and response to fenofibrate. Located in intercellular canaliculus and plasma membrane. Is expressed in alimentary system and liver. Used to study cholecystitis; cholestasis; hepatocellular carcinoma; intrahepatic cholestasis; and primary sclerosing cholangitis. Human ortholog(s) of this gene implicated in cholestasis (multiple); gallbladder disease; and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Apr 2022]

Abcb4 Products (1)

mRNA Protein Name
NM_008830.2 NP_032856.2 phosphatidylcholine translocator ABCB4

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in bile acid secretion IMP
IMP: Inferred from mutant phenotype
8106172 MGI
involved in response to fenofibrate IDA
IDA: Inferred from direct assay
8615769 MGI
NOT involved in xenobiotic transmembrane transport IDA
IDA: Inferred from direct assay
1990275 MGI
Cellular Component GO Annotation Evidence References Source
located in intercellular canaliculus IDA
IDA: Inferred from direct assay
12068294 MGI
located in membrane IDA
IDA: Inferred from direct assay
11279518 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
8615769 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylcholine translocator ABCB4

  • ATP-binding cassette sub-family B member 4

  • P glycoprotein 2

  • P-glycoprotein 3

  • multidrug resistance protein 2

  • multidrug resistance protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183032 ABC transporter modulator-1 Activator 96.30% Unkown
HY-183033 ABC transporter modulator-2 Activator 96.89% Unkown
HY-183034 ABC transporter modulator-3 Activator 97.0% Unkown
HY-183035 ABC transporter modulator-4 Modulator / Unkown
HY-183036 ABC transporter modulator-5 Modulator / Unkown
HY-RS00051 ABCB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21466 Abcb4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27984 Abcb4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcb4 NCBI NCBI:5244