Phb - prohibitin Gene

Also Known as Phb1; Bap32

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18673

Summary

Enables transcription corepressor activity. Involved in several processes, including CD40 signaling pathway; activation of Phospholipase C activity; and positive regulation of macromolecule metabolic process. Acts upstream of or within DNA biosynthetic process and negative regulation of transcription by RNA polymerase II. Located in several cellular components, including cell surface; mitochondrial inner membrane; and nucleus. Is expressed in ectoplacental cone; embryo; and extraembryonic ectoderm. Human ortholog(s) of this gene implicated in breast Cancer and sporadic breast Cancer. Orthologous to human PHB (prohibitin). [provided by Alliance of Genome Resources, Apr 2022]

Phb Products (1)

mRNA Protein Name
NM_008831.4 NP_032857.1 prohibitin 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20959514 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
18480465 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell activation IDA
IDA: Inferred from direct assay
23241883 MGI
acts upstream of or within DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
18480465 MGI
involved in modulation by host of viral RNA genome replication IDA
IDA: Inferred from direct assay
29324904 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18480465 MGI
involved in positive regulation of immunoglobulin production IDA
IDA: Inferred from direct assay
23241883 MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
23241883 MGI
involved in symbiont entry into host cell IDA
IDA: Inferred from direct assay
29324904 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
22417827 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
29324904 MGI
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
20959514 MGI
part of mitochondrial prohibitin complex IPI
IPI: Inferred from physical interaction
20959514 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
11884367 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18480465 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
29324904 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prohibitin 1

  • B-cell receptor-associated protein 32

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114989 Fluorizoline Inducer 99.77% Unkown
HY-152093 YL-939 Inhibitor 99.03% Unkown
HY-117113 JI051 Inhibitor 98.0% Unkown
HY-W008235 Fmoc-N-Me-Ala-OH 99.92% Unkown
HY-124484 JI130 Inhibitor 99.41% Unkown
HY-162904 BPU17 98.16% Unkown
HY-RS16807 Phb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-141475 Acetoacetyl coenzyme A sodium / Unkown
HY-179574 AURKA-IN-4 Inhibitor 99.88% Unkown
HY-RS10407 PHB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10408 PHB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17295 Phb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23247 Phb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23750 Phb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown