Serpinf2 - serine (or cysteine) peptidase inhibitor, clade F, member 2 Gene

Also Known as Pli; Serpimf2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18816

Summary

Predicted to enable protease binding activity; protein homodimerization activity; and serine-type endopeptidase inhibitor activity. Involved in several processes, including Collagen fibril organization; maintenance of blood vessel diameter homeostasis by renin-angiotensin; and positive regulation of biosynthetic process. Located in collagen-containing extracellular matrix. Is expressed in several structures, including liver; pancreas epithelium; urinary system; and yolk sac. Used to study alpha-2-plasmin inhibitor deficiency. Human ortholog(s) of this gene implicated in COVID-19 and alpha-2-plasmin inhibitor deficiency. Orthologous to human SERPINF2 (Serpin family F member 2). [provided by Alliance of Genome Resources, Apr 2022]

Serpinf2 Products (1)

mRNA Protein Name
NM_008878.2 NP_032904.1 alpha-2-antiplasmin precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
18436805 MGI
involved in collagen fibril organization IMP
IMP: Inferred from mutant phenotype
17958745 MGI
involved in maintenance of blood vessel diameter homeostasis by renin-angiotensin IMP
IMP: Inferred from mutant phenotype
18436805 MGI
involved in positive regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
20008146 MGI
involved in positive regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
18436805 MGI
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
18436805 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17958745 MGI
involved in positive regulation of transforming growth factor beta production IMP
IMP: Inferred from mutant phenotype
17958745 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-2-antiplasmin

  • alpha-2-AP

  • alpha-2-PI

  • alpha-2-plasmin inhibitor

  • pigment epithelium derived factor

  • plasmin inhibitor alpha 2

  • serine (or cysteine) proteinase inhibitor, clade F, member 2

  • serpin F2

Recombinant Serpinf2 Proteins

Cat. No. Product Name Accession Purity
HY-P71295 Alpha-2-Antiplasmin/Serpin F2 Protein, Mouse (HEK293, His) Q61247 (V28-K491) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12726 SERPINF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19292 Serpinf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25782 Serpinf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Serpinf2 NCBI NCBI:5345