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Ppargc1a - peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Gene

Also Known as Pgc1; PGC-1; Pgco1; Gm11133; Ppargc1; Pgc-1alpha; A830037N07Rik; PPARGC-1-alpha

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19017

About Ppargc1a

Chromosome 5: 51,611,592-51,725,068 reverse strand.GRCm39:CM000998.3

This gene has 5 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 99 phenotypes. Broad expression in heart adult (RPKM 4.1), frontal lobe adult (RPKM 3.9) and 22 other tissues.

Summary

This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Ppargc1a Products (6)

mRNA	Protein	Name
NM_001402989.1	NP_001389918.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform d
NM_001402988.1	NP_001389917.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform c
NM_001402991.1	NP_001389920.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform e
NM_001402990.1	NP_001389919.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform e
NM_001402987.1	NP_001389916.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b
NM_008904.3	NP_032930.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15681609	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19345188	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	17952069	MGI
enables lncRNA binding	IPI IPI: Inferred from physical interaction	27760051	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14729567	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	17476214	MGI
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	16271724	MGI
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	19345188	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in adipose tissue development	IMP IMP: Inferred from mutant phenotype	22237023	MGI
acts upstream of or within cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	20566846	MGI
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	17476214	MGI
acts upstream of energy homeostasis	IMP IMP: Inferred from mutant phenotype	19345188	MGI
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	23150719	MGI
involved in gluconeogenesis	IDA IDA: Inferred from direct assay	15716268	MGI
acts upstream of or within mitochondrion organization	IDA IDA: Inferred from direct assay	27760051	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	27760051	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20566846	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20566846	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19651776	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14744933	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20661474	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	15454086	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15199055	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21106753	MGI
involved in regulation of circadian rhythm	IDA IDA: Inferred from direct assay	17476214	MGI
acts upstream of or within respiratory electron transport chain	IDA IDA: Inferred from direct assay	14744933	MGI
acts upstream of or within response to dietary excess	IDA IDA: Inferred from direct assay	24726645	MGI
acts upstream of or within response to muscle activity	IDA IDA: Inferred from direct assay	20086200	MGI
involved in response to muscle activity	IMP IMP: Inferred from mutant phenotype	21106753	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	17952069	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ppargc1a Protein Structure

RRM_PPARGC1A

0
200
400
600
797 a.a.

Protein Preferred Names	Protein Names
peroxisome proliferator-activated receptor gamma coactivator 1-alpha	PPAR-gamma coactivator 1-alpha

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10930	Ppargc1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10928	PPARGC1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10929	Ppargc1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppargc1a	NCBI	NCBI:10891