2. Gene
  3. Ppargc1a - peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Gene

Ppargc1a - peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pgc1; PGC-1; Pgco1; Gm11133; Ppargc1; Pgc-1alpha; A830037N07Rik; PPARGC-1-alpha

Gene ID: 19017 | Gene type: protein coding

About Ppargc1a

Chromosome 5: 51,611,592-51,725,068 reverse strand.GRCm39:CM000998.3

This gene has 5 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 99 phenotypes. Broad expression in heart adult (RPKM 4.1), frontal lobe adult (RPKM 3.9) and 22 other tissues.

Summary

This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Ppargc1a Products(6)

mRNA Protein Name
NM_001402989.1 NP_001389918.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform d
NM_001402988.1 NP_001389917.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform c
NM_001402991.1 NP_001389920.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform e
NM_001402990.1 NP_001389919.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform e
NM_001402987.1 NP_001389916.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b
NM_008904.3 NP_032930.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform a

Ppargc1a Protein Structure

RRM_PPARGC1A

RRM_PPARGC1A: cd12623 (673 - 763)

  • 0
  • 200
  • 400
  • 600
  • 797 a.a.
Protein Preferred Names Protein Names

peroxisome proliferator-activated receptor gamma coactivator 1-alpha

PPAR-gamma coactivator 1-alpha

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10928 PPARGC1A Human Pre-designed siRNA Set A / Unkown
HY-RS10929 Ppargc1a Mouse Pre-designed siRNA Set A / Unkown
HY-RS10930 Ppargc1a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppargc1a NCBI NCBI:10891