Ctsa - cathepsin A Gene

Also Known as PPCA; Ppgb

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19025

Summary

This gene encodes a glycoprotein with deamidase, esterase and Carboxypeptidase activities. The encoded protein associates with and provides a protective function to the lysosomal Enzymes beta-galactosidase and neuraminidase. Deficiency of the related gene in humans results in galactosialidosis. The proprotein is processed into two shorter chains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

Ctsa Products (2)

mRNA Protein Name
NM_001038492.2 NP_001033581.1 lysosomal protective protein isoform b preproprotein
NM_008906.4 NP_032932.2 lysosomal protective protein isoform a preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9425240 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of chaperone-mediated autophagy IMP
IMP: Inferred from mutant phenotype
12505983 MGI
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
12505983 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysosomal protective protein

  • carboxypeptidase C

  • carboxypeptidase L

  • protective protein cathepsin A

  • protective protein for beta-galactosidase

Recombinant Ctsa Proteins

Cat. No. Product Name Accession Purity
HY-P74346 Cathepsin A Protein, Mouse (HEK293, His) P16675 (A24-Y474) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03321 CTSA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18752 Ctsa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25239 Ctsa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsa NCBI NCBI:5476