Ppm1a - protein phosphatase 1A, magnesium dependent, alpha isoform Gene

Also Known as MMPa-2; MPPa-1; 2310003C21Rik; 2900017D14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19042

Summary

Enables phosphoprotein Phosphatase activity. Involved in N-terminal protein myristoylation. Acts upstream of or within several processes, including negative regulation of BMP signaling pathway; positive regulation of protein export from nucleus; and protein dephosphorylation. Located in cytosol; membrane; and nucleus. Is expressed in several structures, including Peyer's patch; brain; ganglia; male reproductive gland or organ; and white fat. Orthologous to human PPM1A (protein Phosphatase, Mg2+/Mn2+ dependent 1A). [provided by Alliance of Genome Resources, Apr 2022]

Ppm1a Products (1)

mRNA Protein Name
NM_008910.3 NP_032936.1 protein phosphatase 1A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphoprotein phosphatase activity IDA
IDA: Inferred from direct assay
14654243 MGI
Biological Process GO Annotation Evidence References Source
involved in N-terminal protein myristoylation IDA
IDA: Inferred from direct assay
23088624 MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus IDA
IDA: Inferred from direct assay
21829547 MGI
acts upstream of or within negative regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
25100727 MGI
acts upstream of or within positive regulation of protein export from nucleus IMP
IMP: Inferred from mutant phenotype
25100727 MGI
acts upstream of or within protein dephosphorylation IDA
IDA: Inferred from direct assay
14664809 MGI
acts upstream of or within protein dephosphorylation IMP
IMP: Inferred from mutant phenotype
25100727 MGI
involved in protein dephosphorylation IMP
IMP: Inferred from mutant phenotype
23088624 MGI
acts upstream of protein export from nucleus IMP
IMP: Inferred from mutant phenotype
25100727 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
23088624 MGI
located in membrane IDA
IDA: Inferred from direct assay
23088624 MGI
located in nucleus IDA
IDA: Inferred from direct assay
21829547 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein phosphatase 1A

  • Mpp alpha

  • PP2C-alpha

  • protein phosphatase IA

Recombinant Ppm1a Proteins

Cat. No. Product Name Accession Purity
HY-P75979 PPM1A Protein, Mouse (His) P49443/NP_032936.1 (M1-W382) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164220 PPM1A-IN-1 Inhibitor 95.71% Unkown
HY-163782 SMIP-031 98.60% Unkown
HY-P10359A TAT-QFNP12 acetate Inhibitor 95.90% Unkown
HY-P10359 TAT-QFNP12 Inhibitor / Unkown
HY-RS10960 PPM1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17113 Ppm1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23558 Ppm1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppm1a NCBI NCBI:5494