PPM1A - protein phosphatase, Mg2+/Mn2+ dependent 1A Gene

Also Known as PP2CA; PP2Calpha; PP2C-ALPHA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5494

About PPM1A

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:60,245,750-60,299,087 (from NCBI)

This gene has 8 transcripts (splice variants), 249 orthologues and 16 paralogues. Ubiquitous expression in bone marrow (RPKM 10.2), brain (RPKM 9.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This Phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This Phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this Phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and Apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

PPM1A Products (3)

mRNA	Protein	Name
NM_021003.5	NP_066283.1	protein phosphatase 1A isoform 1
NM_177951.3	NP_808820.1	protein phosphatase 1A isoform 2
NM_177952.3	NP_808821.2	protein phosphatase 1A isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables R-SMAD binding	IPI IPI: Inferred from physical interaction	16751101	GOA
enables calmodulin-dependent protein phosphatase activity	IDA IDA: Inferred from direct assay	11559703	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10644691	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	10644691	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in dephosphorylation	IDA IDA: Inferred from direct assay	10644691	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	18930133	GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	18930133	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	16751101	GOA
involved in peptidyl-threonine dephosphorylation	IDA IDA: Inferred from direct assay	11559703	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10644691	GOA
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	10644691	GOA
involved in protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	18930133	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	16751101	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPM1A Protein Structure

PP2C

PP2C_C

0
100
200
300
382 a.a.

Protein Preferred Names	Protein Names
protein phosphatase 1A

PPM1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPM1A	P35813	EGFR	Homo sapiens	P00533	Ub Reconstruction	28065597
Intra	PPM1A	P35813	IGF1R	Homo sapiens	P08069	Ub Reconstruction	28065597
Intra	PPM1A	P35813	AXIN1	Homo sapiens	O15169	Anti Bait CoIP	10644691
Intra	PPM1A	P35813	ARRB2	Homo sapiens	P32121	Anti Tag CoIP	17620599
Intra	PPM1A	P35813	MAPK14	Homo sapiens	Q16539	Phosphatase Assay	23560844
Intra	PPM1A	P35813	MAPK1	Homo sapiens	P28482	Pull Down	23560844
Intra	PPM1A	P35813	MAPK1	Homo sapiens	P28482	Phosphatase Assay	23560844
Intra	PPM1A	P35813	RANBP3	Homo sapiens	Q9H6Z4	Anti Bait CoIP	21960005
Intra	PPM1A	P35813	RANBP3	Homo sapiens	Q9H6Z4	Pull Down	21960005

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPM1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71227	PPM1A Protein, Human (His)	P35813-1 (G2-W382)	≥ 95%, as determined by reducing SDS-PAGE.

PPM1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84167	PPM1A Antibody (YA3864)	WB, FC, ELISA	Human, Monkey
HY-P84167A	PPM1A Antibody (YA3864)(PBS only)	WB, FC, ELISA	Human, Monkey

Related Diseases

Diseases	Alias
Buschke-Ollendorff Syndrome	BOS Dermatoosteopoikilosis Dermatofibrosis Lenticularis Disseminata With Osteopoikilosis Osteopathia Condensans Disseminata Dermatofibrosis Lenticularis Disseminata Disseminated Dermatofibrosis With Osteopoikilosis Dermatofibrosis, Disseminated, With Osteopoikilosis Osteopoikilosis With Or Without Melorheostosis Dermatofibrosis, Disseminated With Osteopoikilosis Dermatofibrosis Disseminata Lenticularis Isolated Osteopoikilosis Osteopoikilosis, Isolated
Osteopoikilosis	Osteopathia Condensans Disseminata Spotted Bones Dermatofibrosis Lenticularis Disseminata
Melorheostosis	Candle Wax Disease Flowing Hyperostosis Hyperostosis, Monomelic Leri Syndrome Leri'S Disease Melorheostoses Melorheostosis Of Leri Melorheostosis, Isolated Periostitis Monomelic Rheostosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-164220	PPM1A-IN-1	Inhibitor	95.71%	Unkown
HY-163782	SMIP-031		98.60%	Unkown
HY-P10359A	TAT-QFNP12 acetate	Inhibitor	95.90%	Unkown
HY-P10359	TAT-QFNP12	Inhibitor	/	Unkown
HY-RS10960	PPM1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17113	Ppm1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23558	Ppm1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPM1A	MGD	MGI:99878
Canis familiaris	PPM1A	VGNC	VGNC:44862
Felis catus	PPM1A	VGNC	VGNC:68992
Macaca mulatta	PPM1A	VGNC	VGNC:84422
Rattus norvegicus	PPM1A	RGD	RGD:3373
Others	PPM1A	NCBI