Eif2ak2 - eukaryotic translation initiation factor 2-alpha kinase 2 Gene

Also Known as Pkr; Tik; Prkr; 2310047A08Rik; 4732414G15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19106

Summary

Enables double-stranded RNA binding activity and protein kinase activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of intracellular signal transduction; and regulation of hematopoietic stem cell differentiation. Acts upstream of or within cellular protein metabolic process; endoplasmic reticulum unfolded protein response; and negative regulation of apoptotic process. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Eif2ak2 Products (1)

mRNA Protein Name
NM_011163.4 NP_035293.1 interferon-induced, double-stranded RNA-activated protein kinase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
21703541 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7519779 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
7519779 MGI
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
21123651 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within endoplasmic reticulum unfolded protein response IDA
IDA: Inferred from direct assay
15542627 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
15542627 MGI
involved in negative regulation of viral genome replication IMP
IMP: Inferred from mutant phenotype
20038207 MGI
involved in positive regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
20038207 MGI
involved in positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
20038207 MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
20038207 MGI
involved in positive regulation of stress-activated MAPK cascade IMP
IMP: Inferred from mutant phenotype
20038207 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
7519779 MGI
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
22801494 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
7519779 MGI
involved in regulation of NLRP3 inflammasome complex assembly IMP
IMP: Inferred from mutant phenotype
22801494 MGI
involved in regulation of hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
23403623 MGI
involved in regulation of hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
23403623 MGI
involved in regulation of hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
23403623 MGI
acts upstream of or within translation IDA
IDA: Inferred from direct assay
7519779 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon-induced, double-stranded RNA-activated protein kinase

  • IFN- type I-induced and dsRNA-activated kinase

  • IFN-induced and double-stranded RNA-activated kinase

  • P1/eIF-2A protein kinase

  • T-cell viral integration site

  • dsRNA-activated kinase

  • eIF-2 alpha

  • eIF-2A protein kinase 2

  • interferon-inducible RNA-dependent

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04243 EIF2AK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174720 Human EIF2AK2 mRNA / Unkown
HY-RS18207 Eif2ak2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24684 Eif2ak2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif2ak2 NCBI NCBI:5610