St14 - suppression of tumorigenicity 14 (colon carcinoma) Gene

Also Known as mCAP3; MT-SP1; Prss14; Epithin; Tmprss14; matriptase

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19143

Summary

Enables serine-type endopeptidase activity. Acts upstream of or within epithelial cell morphogenesis involved in placental branching and neural tube closure. Located in extracellular region. Is extrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; pituitary gland; and sensory organ. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase). [provided by Alliance of Genome Resources, Apr 2022]

St14 Products (1)

mRNA Protein Name
NM_011176.4 NP_035306.2 suppressor of tumorigenicity 14 protein homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables serine-type endopeptidase activity EXP
EXP: Inferred from Experiment
20657595 MGI
enables serine-type peptidase activity IDA
IDA: Inferred from direct assay
11567025 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within epithelial cell morphogenesis involved in placental branching IGI
IGI: Inferred from genetic interaction
19592578 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
19592578 MGI
involved in proteolysis IDA
IDA: Inferred from direct assay
11567025 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
11567025 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
11567025 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

suppressor of tumorigenicity 14 protein homolog

  • matriptase/MT-SP1

  • protease, serine, 14 (epithin)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS17968 St14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13844 ST14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24439 St14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens St14 NCBI NCBI:6768