Lrrc4 - leucine rich repeat containing 4 Gene

Also Known as NGL2; MBAG1; NGL-2; NLG-2; Nag14

Species: Mus musculus

Gene Type: protein coding
Gene ID: 192198

Summary

Involved in modulation of chemical synaptic transmission. Acts upstream of or within excitatory synapse assembly and postsynaptic density protein 95 clustering. Located in several cellular components, including dendritic spine; glutamatergic synapse; and postsynaptic membrane. Is active in Schaffer collateral - CA1 synapse. Is integral component of postsynaptic density membrane. Is expressed in several structures, including branchial arch; central nervous system; metanephros; sensory organ; and vibrissa. Orthologous to human LRRC4 (leucine rich repeat containing 4). [provided by Alliance of Genome Resources, Apr 2022]

Lrrc4 Products (2)

mRNA Protein Name
NM_138682.2 NP_619623.2 leucine-rich repeat-containing protein 4 precursor
NM_138682.2 NP_619623.2 leucine-rich repeat-containing protein 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16980967 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within excitatory synapse assembly IMP
IMP: Inferred from mutant phenotype
16980967 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
25411505 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
25411505 MGI
acts upstream of or within postsynaptic density protein 95 clustering IDA
IDA: Inferred from direct assay
16980967 MGI
acts upstream of or within synapse organization IDA
IDA: Inferred from direct assay
16980967 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
25411505 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
16980967 MGI
located in excitatory synapse IDA
IDA: Inferred from direct assay
16980967 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25411505 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25411505 MGI
located in neuron spine IDA
IDA: Inferred from direct assay
16980967 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
25411505 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
16980967 MGI
located in synapse IDA
IDA: Inferred from direct assay
16980967 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-rich repeat-containing protein 4

  • LIBG-like protein

  • LRRC4-like protein

  • brain tumor-associated protein MBAG1

  • netrin-G2 ligand

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07818 LRRC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07821 LRRC4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07822 LRRC4C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18668 Lrrc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20174 Lrrc4c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25154 Lrrc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26678 Lrrc4c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992426 NS101 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrrc4 NCBI NCBI:64101