Ptprs - protein tyrosine phosphatase, receptor type, S Gene

Also Known as PTP; Ptpt9; PTP-NU3; PTPNU-3; R-PTP-S; PTPsigma; RPTPsigma

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19280

Summary

Enables chondroitin sulfate binding activity; heparin binding activity; and protein tyrosine Phosphatase activity. Involved in several processes, including negative regulation of neuron projection development; peptidyl-tyrosine dephosphorylation; and regulation of postsynaptic density assembly. Acts upstream of or within central nervous system development and establishment of endothelial intestinal barrier. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and plasma membrane. Is integral component of presynaptic membrane. Is expressed in several structures, including adipose tissue; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human PTPRS (protein tyrosine Phosphatase receptor type S). [provided by Alliance of Genome Resources, Apr 2022]

Ptprs Products (4)

mRNA Protein Name
NM_001252453.1 NP_001239382.1 receptor-type tyrosine-protein phosphatase S isoform 2 precursor
NM_001252455.1 NP_001239384.1 receptor-type tyrosine-protein phosphatase S isoform 3 precursor
NM_001252456.1 NP_001239385.1 receptor-type tyrosine-protein phosphatase S isoform 2 precursor
NM_011218.2 NP_035348.2 receptor-type tyrosine-protein phosphatase S isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chondroitin sulfate binding IDA
IDA: Inferred from direct assay
22406547 MGI
enables heparin binding IDA
IDA: Inferred from direct assay
22406547 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24385580 MGI
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
7529177 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cerebellum development IMP
IMP: Inferred from mutant phenotype
15842738 MGI
acts upstream of or within cerebral cortex development IMP
IMP: Inferred from mutant phenotype
15842738 MGI
acts upstream of or within corpus callosum development IMP
IMP: Inferred from mutant phenotype
15842738 MGI
acts upstream of or within establishment of endothelial intestinal barrier IMP
IMP: Inferred from mutant phenotype
24385580 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
15842738 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
22519304 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
22519304 MGI
involved in negative regulation of axon extension IMP
IMP: Inferred from mutant phenotype
19780196 MGI
involved in negative regulation of axon regeneration IMP
IMP: Inferred from mutant phenotype
19780196 MGI
involved in negative regulation of collateral sprouting IMP
IMP: Inferred from mutant phenotype
22519304 MGI
involved in negative regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
22519304 MGI
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
22406547 MGI
involved in peptidyl-tyrosine dephosphorylation IDA
IDA: Inferred from direct assay
7529177 MGI
acts upstream of or within peptidyl-tyrosine dephosphorylation IMP
IMP: Inferred from mutant phenotype
24385580 MGI
involved in regulation of postsynaptic density assembly IDA
IDA: Inferred from direct assay
21262467 MGI
involved in regulation of postsynaptic density assembly IMP
IMP: Inferred from mutant phenotype
21262467 MGI
acts upstream of or within spinal cord development IMP
IMP: Inferred from mutant phenotype
15842738 MGI
involved in synapse organization IDA
IDA: Inferred from direct assay
22519304 MGI
involved in synapse organization IMP
IMP: Inferred from mutant phenotype
22519304 MGI
involved in trans-synaptic signaling IDA
IDA: Inferred from direct assay
32142410 MGI
involved in trans-synaptic signaling IMP
IMP: Inferred from mutant phenotype
32142410 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
22519304 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
22519304 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21262467 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21262467 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
26231120 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
21262467 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase S

  • R-PTP-sigma

  • Receptor-type tyrosine-protein phosphatase sigma

  • tissue-specific protein tyrosine phosphatase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11449 PTPRS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21709 Ptprs Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28227 Ptprs Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptprs NCBI NCBI:5802