Rbp4 - retinol binding protein 4, plasma Gene

Also Known as Rbp-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19662

Summary

Enables retinol binding activity. Involved in several processes, including animal organ development; gluconeogenesis; and negative regulation of cardiac muscle cell proliferation. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; retinoid metabolic process; and terpenoid transport. Located in extracellular space. Is expressed in several structures, including adipose tissue; brain; genitourinary system; gut; and hindlimb. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Rbp4 Products (2)

mRNA Protein Name
NM_001159487.1 NP_001152959.1 retinol-binding protein 4 isoform 1
NM_011255.3 NP_035385.1 retinol-binding protein 4 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23105095 MGI
enables retinol binding IDA
IDA: Inferred from direct assay
12484775 MGI
Biological Process GO Annotation Evidence References Source
involved in cardiac muscle tissue development IMP
IMP: Inferred from mutant phenotype
12663486 MGI
acts upstream of or within detection of light stimulus involved in visual perception IMP
IMP: Inferred from mutant phenotype
12484775 MGI
acts upstream of or within embryo development IGI
IGI: Inferred from genetic interaction
18093970 MGI
involved in embryonic organ morphogenesis IMP
IMP: Inferred from mutant phenotype
15994349 MGI
involved in embryonic retina morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
10469643 MGI
involved in embryonic skeletal system development IMP
IMP: Inferred from mutant phenotype
15994349 MGI
involved in eye development IMP
IMP: Inferred from mutant phenotype
15994349 MGI
involved in female genitalia morphogenesis IMP
IMP: Inferred from mutant phenotype
15994349 MGI
involved in gluconeogenesis IMP
IMP: Inferred from mutant phenotype
16034410 MGI
involved in heart development IMP
IMP: Inferred from mutant phenotype
15994349 MGI
involved in heart trabecula formation IMP
IMP: Inferred from mutant phenotype
12663486 MGI
involved in lung development IMP
IMP: Inferred from mutant phenotype
15994349 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
16586441 MGI
involved in negative regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
12663486 MGI
involved in positive regulation of immunoglobulin production IDA
IDA: Inferred from direct assay
10944490 MGI
acts upstream of or within response to insulin IMP
IMP: Inferred from mutant phenotype
16034410 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
11562477 MGI
acts upstream of or within retinal metabolic process IMP
IMP: Inferred from mutant phenotype
11562477 MGI
acts upstream of or within retinol metabolic process IGI
IGI: Inferred from genetic interaction
18093970 MGI
acts upstream of or within retinol transport IGI
IGI: Inferred from genetic interaction
23105095 MGI
acts upstream of or within retinol transport IMP
IMP: Inferred from mutant phenotype
11562477 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
16586441 MGI
involved in urinary bladder development IMP
IMP: Inferred from mutant phenotype
15994349 MGI
involved in uterus development IMP
IMP: Inferred from mutant phenotype
15994349 MGI
involved in vagina development IMP
IMP: Inferred from mutant phenotype
15994349 MGI
acts upstream of or within vitamin A import into cell IMP
IMP: Inferred from mutant phenotype
12484775 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
16034410 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

retinol-binding protein 4

  • PRBP

  • RBP

  • plasma retinol-binding protein

  • retinol binding protein 4, cellular

Recombinant Rbp4 Proteins

Cat. No. Product Name Accession Purity
HY-P74599 RBP4 Protein, Mouse (HEK293, His) Q00724 (E19-L201) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-123623 Tinlarebant Antagonist 98.05% Phase 3
HY-172232 STG-001 / Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107633 A 1120 99.73% Unkown
HY-143793 RBP4 inhibitor 1 Inhibitor 99.49% Unkown
HY-147366 RBP4 ligand-1 Inhibitor / Unkown
HY-182385 BPN-14136 Inhibitor / Unkown
HY-185132 RBP4-IN-2 Inhibitor / Unkown
HY-185133 RBP4-IN-3 Inhibitor / Unkown
HY-RS10845 POLR2D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11769 RBP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16888 Rbp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23330 Rbp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rbp4 NCBI NCBI:5950