Relb - avian reticuloendotheliosis viral (v-rel) oncogene related B Gene

Also Known as shep

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19698

About Relb

Chromosome 7: 19,340,142-19,363,363 reverse strand.GRCm39:CM001000.3

This gene has 10 transcripts (splice variants), 195 orthologues, 4 paralogues and is associated with 108 phenotypes. Broad expression in spleen adult (RPKM 33.2), adrenal adult (RPKM 28.7) and 15 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in circadian regulation of gene expression; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including NIK/NF-kappaB signaling; antigen processing and presentation; and mononuclear cell differentiation. Located in cytosol and nucleus. Is expressed in axial skeleton; eye; heart; and ureter. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in breast Cancer and immunodeficiency 53. Orthologous to human RelB (RelB proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

Relb Products (2)

mRNA	Protein	Name
NM_009046.2	NP_033072.2	transcription factor RelB isoform 1
NM_001290457.1	NP_001277386.1	transcription factor RelB isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15944286	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	23583643	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22894897	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	16154093	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11931770	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within T-helper 1 cell differentiation	IMP IMP: Inferred from mutant phenotype	16081776	MGI
acts upstream of or within T-helper 1 type immune response	IMP IMP: Inferred from mutant phenotype	7845467	MGI
acts upstream of or within antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	7845467	MGI
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22894897	MGI
acts upstream of or within myeloid dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	7845467	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22894897	MGI
involved in non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23583643	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	11931770	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11931770	MGI
is active in synapse	IDA IDA: Inferred from direct assay	22514330	MGI
is active in synapse	IEP IEP: Inferred from expression pattern	22514330	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Relb Protein Structure

RelB_leu_zip

RHD-n_RelB

RHD_dimer

RelB_transactiv

0
100
200
300
400
500
558 a.a.

Protein Preferred Names	Protein Names
transcription factor RelB

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14645	(-)-DHMEQ	Inhibitor	99.81%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Relb	NCBI	NCBI:5971