AHSG - alpha 2-HS glycoprotein Gene

Also Known as AHS; A2HS; HSGA; APMR1; FETUA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 197

About AHSG

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,613,060-186,621,318 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues, 3 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 1605.5).

Summary

The protein encoded by this gene is a negatively-charged serum glycoprotein that is synthesized by hepatocytes. The encoded protein consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several processes, including endocytosis, brain development, and the formation of bone tissue. Defects in this gene are a cause of susceptibility to leanness. [provided by RefSeq, Aug 2017]

AHSG Products (4)

mRNA Protein Name
NM_001354571.2 NP_001341500.1 alpha-2-HS-glycoprotein isoform 1 preproprotein
NM_001354572.2 NP_001341501.1 alpha-2-HS-glycoprotein isoform 3 preproprotein
NM_001354573.2 NP_001341502.1 alpha-2-HS-glycoprotein isoform 4 preproprotein
NM_001622.4 NP_001613.2 alpha-2-HS-glycoprotein isoform 2 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in acute-phase response IDA
IDA: Inferred from direct assay
12153747 GOA
involved in positive regulation of phagocytosis IDA
IDA: Inferred from direct assay
12725640 GOA
involved in regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
12642050 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AHSG Protein Structure

Cystatin

Cystatin: Cystatin domain (153 - 237)

  • 0
  • 100
  • 200
  • 300
  • 367 a.a.
Protein Preferred Names Protein Names

alpha-2-HS-glycoprotein

  • alpha-2-Z-globulin

AHSG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AHSG P02765 POTEF Homo sapiens A5A3E0
Anti Tag CoIP
33961781
Intra
AHSG P02765 POTEF Homo sapiens A5A3E0
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AHSG Proteins

Cat. No. Product Name Accession Purity
HY-P70170 Fetuin A/AHSG Protein, Human (HEK293, His) AAH48198.1/NP_001613.2 (A19-V367) ≥ 95%, as determined by reducing SDS-PAGE.

AHSG Antibodies

Cat. No. Product Name Application Reactivity
HY-P83079 Fetuin A Antibody (YA2824) WB Human
HY-P83079A Fetuin A Antibody (YA2824)(PBS only) WB Human

Related Diseases

Diseases Alias
Alopecia-Mental Retardation Syndrome 1

  • APMR1

  • Alopecia-Intellectual Disability Syndrome 1

  • Amr Syndrome

  • Alopecia-Intellectual Disability Syndrome

  • Amr Syndrome 1

  • Alopecia With Severe Intellectual Deficit

  • Apmr

  • Alopecia Intellectual Disbility Syndrome 1

  • Perniola-Krajewska-Carnevale Syndrome

  • Alopecia - Intellectual Disability Syndrome

  • Alopecia With Mental Retardation Syndrome 1

  • Perniola Krajewska Carnevale Syndrome
Epstein-Barr Virus Hepatitis
Uremia

  • Uremia Of Renal Origin
Calcinosis

  • Pathologic Calcification

  • Pathologically Calcified Structure
Alcoholic Liver Cirrhosis

  • Alcoholic Cirrhosis

  • Portal Cirrhosis

  • Alcoholic Cirrhosis Of Liver

  • Liver Cirrhosis, Alcoholic

  • Laennec'S Cirrhosis

  • Laennec'S Cirrhosis, Alcoholic

  • Alcohol Cirrhosis

  • Alcoholic Laennec Cirrhosis

  • Alcoholic Cirrhosis Nos

  • Etoh Cirrhosis

  • Alcohol Hepatic Cirrhosis

  • Alcohol Liver Cirrhosis

  • Laennec Cirrhosis
Alopecia
Non-Alcoholic Fatty Liver Disease

  • Fatty Liver

  • Non-Alcoholic Fatty Liver

  • Nafld

  • Nonalcoholic Fatty Liver Disease

  • Nonalcoholic Steatohepatitis

  • Steatosis

  • Nafl

  • Nash

  • Non-Alcoholic Steatohepatitis

  • Susceptibility To Nonalcoholic Fatty Liver Disease

  • Steatohepatitis

  • Fatty Degeneration

  • Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

  • Nafld Without Nash

  • Nafld Without Mention Of Nash
Alopecia-Mental Retardation Syndrome
Endometriosis

  • Endometriosis, Site Unspecified

  • Endometrial Ectopia
Nephrolithiasis

  • Kidney Stones

  • Stone - Kidney/Ureter

  • Kidney Calculi
Calciphylaxis

  • Idiopathic Calciphylaxis
Chronic Kidney Disease

  • Chronic Renal Disease

  • Chronic Kidney Failure

  • Ckd

  • Chronic Renal Failure

  • Kidney Failure, Chronic

  • Chronic Renal Failure Syndrome

  • Crf

  • Renal Failure - Chronic

  • Renal Failure Chronic

  • Chronic Kidney Diseases

  • Chronic Kidney Disease Stage 5

  • Ckd - [Chronic Kidney Disease]

  • Crf - [Chronic Renal Failure]

  • Chronic Kidney Impairment

  • Chronic Renal Impairment

  • Chronic Kidney Shutdown

  • Chronic Hypoxic Kidney Failure

  • Chronic Kidney Collapse

  • Chronic Renal Insufficiency

  • Chronic Kidney Toxaemia

  • Chronic Kidney Hypofunction

  • Chronic Renal Suppression

  • Chronic Renal Failure, Stage 5

  • Ckd - [Chronic Kidney Disease] Stage 5

  • End Stage Kidney Failure

  • End Stage Renal Failure

  • End Stage Kidney Disease

  • End Stage Renal Disease

  • End Stage Chronic Renal Failure

  • Esrf - [End Stage Renal Failure]

  • Esrd - [End Stage Renal Diseases]

  • Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Thrombophilia Due To Hrg Deficiency

  • Hereditary Thrombophilia Due To Congenital Histidine-Rich Glycoprotein Deficiency

  • Hereditary Thrombophilia Due To Congenital Hrg Deficiency

  • Thph11
Gestational Diabetes

  • Gestational Diabetes Mellitus

  • GDM

  • Diabetes Mellitus Arising In Pregnancy

  • Maternal Gestational Diabetes Mellitus

  • Diabetes Mellitus, Gestational

  • Diabetes Mellitus, Pregnancy Related

  • Diabetes, Pregnancy-Induced

  • Diabetes Gestational

  • Diabetes, Gestational

  • Diabetes Of Pregnancy

  • Gdm - [Gestational Diabetes Mellitus]

  • Gestational Diabetes Mellitus Nos

  • Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium
Fatty Liver Disease

  • Alcoholic Fatty Liver

  • Fatty Liver

  • Fatty Liver, Alcoholic

  • Fatty Change Of Liver

  • Hepatic Lipidosis

  • Steatosis Of Liver

  • Fatty Liver Alcoholic

  • Steatohepatitis

  • Etoh Fatty Liver

  • Etoh Fatty Liver Metamorphosis

  • Fatty Etoh Liver Necrosis
Phosphorus Metabolism Disease

  • Phosphorus Metabolism Disorders

  • Disorder Of Phosphorus Metabolism

  • Phosphorus Disorder

  • Phosphorus Metabolism Disorder
Arterial Calcification Of Infancy

  • Idiopathic Infantile Arterial Calcification

  • Generalized Arterial Calcification Of Infancy

  • Iiac

  • Occlusive Infantile Arteriopathy

  • Infantile Arteriosclerosis

  • Gaci

  • Idiopathic Obliterative Arteriopathy

  • Generalized Arterial Calcification In Infancy

  • Arteriopathia Calcificans Infantum

  • Diffuse Arterial Calcifying Elastopathy Of Infancy

  • Infantile Calcifying Arteriopathy

  • Medial Coronary Sclerosis Of Infancy

  • Coronary Sclerosis, Medial, Of Infancy

  • Calcification, Arterial, Generalized, Infancy
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Kidney Disease

  • Renal Failure

  • Kidney Failure

  • Kidney Diseases

  • Nephropathy

  • Abnormality Of The Kidney

  • Impaired Renal Function Disease

  • Renal Anomaly

  • Kidney Dysfunction

  • Renal Disease

  • Nephropathies

  • Renal Failure Adverse Event

  • Abnormal Renal Function
Vitamin K Deficiency Bleeding

  • Vitamin K Deficiency

  • Deficiency Of Vitamin K

  • Vitamin K

  • Vitamin K Deficiency Hemorrhagic Disease
Angioid Streaks
Caffey Disease

  • Infantile Cortical Hyperostosis

  • CAFYD

  • Cortical Congenital Hyperostosis

  • Caffey-Silverman Syndrome

  • De Toni-Caffey Disease

  • Hyperostosis Cortical Infantile

  • Hyperostosis, Cortical, Congenital
Mineral Metabolism Disease

  • Mineral Metabolism Disorder

  • Disorder Of Mineral Metabolism
Sialolithiasis

  • Sialolith

  • Stone Of Salivary Gland Or Duct

  • Salivary Gland Calculi

  • Salivary Gland Stone

  • Calculus Of Salivary Gland Or Duct

  • Calculus Of Salivary Gland

  • Salivary Calculus

  • Salivary Gland Calculus

  • Salivary Stone

  • Salivary Duct Calculi

  • Sialodocholithiasis
Diabetes Mellitus

  • Diabetes
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00486 AHSG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18226 Ahsg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24703 Ahsg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus AHSG VGNC VGNC:102593
Bos taurus AHSG VGNC VGNC:25756
Mus musculus AHSG MGD MGI:107189
Canis familiaris AHSG VGNC VGNC:37731
Macaca mulatta AHSG VGNC VGNC:69757
Rattus norvegicus AHSG RGD RGD:2075
Others AHSG NCBI