LDHD - lactate dehydrogenase D Gene

Also Known as DLD; DLACD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 197257

About LDHD

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:75,111,864-75,116,780 (from NCBI)

This gene has 4 transcripts (splice variants), 188 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 28.2), liver (RPKM 23.6) and 15 other tissues.

Summary

The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

LDHD Products (2)

mRNA Protein Name
NM_153486.4 NP_705690.2 probable D-lactate dehydrogenase, mitochondrial isoform 1 precursor
NM_194436.3 NP_919417.1 probable D-lactate dehydrogenase, mitochondrial isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12127981 GOA
Biological Process GO Annotation Evidence References Source
involved in lactate catabolic process IMP
IMP: Inferred from mutant phenotype
30931947 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LDHD Protein Structure

FAD_binding_4

FAD_binding_4: FAD binding domain (66 - 202)

FAD-oxidase_C

FAD-oxidase_C: FAD linked oxidases, C-terminal domain (266 - 506)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 507 a.a.
Protein Preferred Names Protein Names

probable D-lactate dehydrogenase, mitochondrial

  • D-lactate dehydrogenase

LDHD Antibodies

Cat. No. Product Name Application Reactivity
HY-P86942 LDHD Antibody (YA6635) WB, ICC/IF, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
D-Lactic Aciduria With Gout

  • DLACD

  • Uric Acid Concentration, Serum, Quantitative Trait Locus 7

  • Uaqtl7

  • Gout 5

  • Gout, Susceptibility To, 5

  • Gout5

  • D-Lactic Aciduria With Susceptibility To Gout
Gout

  • Gouty Arthritis

  • Articular Gout

  • Gouty Arthropathy

  • Arthritis, Gouty

  • Arthritis Gouty

  • Idiopathic Gout

  • Idiopathic Gout, Unspecified Site

  • Gouty Bursitis

  • Uratic Arthritis

  • Gout Nos

  • Gouty

  • Gouty Diathesis
Cataract 6, Multiple Types

  • Ctpp1

  • Cataract 6 Multiple Types

  • CTRCT6

  • Cataract, Posterior Polar, 1

  • Arcc2

  • Cataract, Age-Related Cortical, 2

  • Ctpa

  • Ctpp

  • Age Related Cortical Cataract 2

  • Posterior Polar Cataract 1

  • Posterior Polar Cataract, 1

  • Age-Related Cortical Cataract 2

  • Cataract Posterior Polar 1
Hyperphenylalaninemia, Bh4-Deficient, A

  • 6-Pyruvoyl-Tetrahydropterin Synthase Deficiency

  • Pts Deficiency

  • HPABH4A

  • Hyperphenylalaninemia, Tetrahydrobiopterin-Deficient, Due To Pts Deficiency

  • Ptsd

  • Bh4-Deficient Hyperphenylalaninemia A

  • Hyperphenylalaninemia Due To 6-Pyruvoyltetrahydropterin Synthase Deficiency

  • Tetrahydobioperin-Deficient Hyperphenylalaninemia Due To Pts Deficiency

  • Hyperphenylalanemia, Bh4-Deficient, A

  • Hyperphenylalaninemia Due To 6-Pyruvoyl-Tetrahydropterin Synthase Deficiency

  • 6-Pyruvoyltetrahydropterin Synthase Deficiency

  • Hyperphenylalaninemia Tetrahydrobiopterin-Deficient Due To Pts Deficiency

  • Ptpsd

  • Hyperphenylalaninemia, Bh4-Deficient, Type A
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07574 LDHD Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LDHD MGD MGI:106428
Bos taurus LDHD VGNC VGNC:30825
Rattus norvegicus LDHD RGD RGD:1308107
Felis catus LDHD VGNC VGNC:63209
Macaca mulatta LDHD VGNC VGNC:74084
Canis familiaris LDHD VGNC VGNC:42621
Others LDHD NCBI